HS in Acute Lung Injury: a Therapeutic Dead End(?)

Overview

Journal Intensive Care Med Exp

Specialty Critical Care

Date 2020 Dec 18

PMID 33336306

Citations 6

Authors

Tamara Merz

Nicole Denoix

Martin Wepler

Holger Gassler

David A C Messerer

Clair Hartmann

Thomas Datzmann

Peter Radermacher

Oscar McCook

Affiliations

Soon will be listed here.

Abstract

This review addresses the plausibility of hydrogen sulfide (HS) therapy for acute lung injury (ALI) and circulatory shock, by contrasting the promising preclinical results to the present clinical reality. The review discusses how the narrow therapeutic window and width, and potentially toxic effects, the route, dosing, and timing of administration all have to be balanced out very carefully. The development of standardized methods to determine in vitro and in vivo HS concentrations, and the pharmacokinetics and pharmacodynamics of HS-releasing compounds is a necessity to facilitate the safety of HS-based therapies. We suggest the potential of exploiting already clinically approved compounds, which are known or unknown HS donors, as a surrogate strategy.

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