Advances in the Role of MiRNAs in the Occurrence and Development of Osteosarcoma

Overview

Journal Open Med (Wars)

Specialty General Medicine

Date 2020 Dec 18

PMID 33336056

Citations 1

Authors

Guanyu Zhang

Yiran Li

Jiasheng Xu

Zhenfang Xiong

Affiliations

Soon will be listed here.

Abstract

Osteosarcoma (OS) is the most common primary malignant tumor of the skeletal system in the clinic. It mainly occurs in adolescent patients and the pathogenesis of the disease is very complicated. The distant metastasis may occur in the early stage, and the prognosis is poor. MicroRNAs (miRNAs) are non-coding RNAs of about 18-25 nt in length that are involved in post-transcriptional regulation of genes. miRNAs can regulate target gene expression by promoting the degradation of target mRNAs or inhibiting the translation process, thereby the proliferation of OS cells can be inhibited and the apoptosis can be promoted; in this way, miRNAs can affect the metabolism of OS cells and can also participate in the occurrence, invasion, metastasis, and recurrence of OS. Some miRNAs have already been found to be closely related to the prognosis of patients with OS. Unlike other reviews, this review summarizes the miRNA molecules closely related to the development, diagnosis, prognosis, and treatment of OS in recent years. The expression and influence of miRNA molecule on OS were discussed in detail, and the related research progress was summarized to provide a new research direction for early diagnosis and treatment of OS.

Citing Articles

MicroRNAs Modulate Signaling Pathways in Osteogenic Differentiation of Mesenchymal Stem Cells.

Mazziotta C, Lanzillotti C, Iaquinta M, Taraballi F, Torreggiani E, Rotondo J Int J Mol Sci. 2021; 22(5).

PMID: 33673409 PMC: 7956574. DOI: 10.3390/ijms22052362.

References

Wen J, Zhao Y, Liu Y, Zhao J . MicroRNA-34a inhibits tumor invasion and metastasis in osteosarcoma partly by effecting C-IAP2 and Bcl-2. Tumour Biol. 2017; 39(6):1010428317705761. DOI: 10.1177/1010428317705761. View

Sun Y, Wang F, Wang L, Jiao Z, Fang J, Li J . MicroRNA-433 regulates apoptosis by targeting PDCD4 in human osteosarcoma cells. Oncol Lett. 2017; 14(2):2353-2358. PMC: 5530199. DOI: 10.3892/ol.2017.6441. View

de Azevedo J, Fernandes T, Fernandes Jr J, Verissimo de Azevedo J, Lanza D, Bezerra C . Biology and pathogenesis of human osteosarcoma. Oncol Lett. 2020; 19(2):1099-1116. PMC: 6955653. DOI: 10.3892/ol.2019.11229. View

Lian F, Cui Y, Zhou C, Gao K, Wu L . Identification of a plasma four-microRNA panel as potential noninvasive biomarker for osteosarcoma. PLoS One. 2015; 10(3):e0121499. PMC: 4361617. DOI: 10.1371/journal.pone.0121499. View

Zhang H, Mai Q, Chen J . MicroRNA-210 is increased and it is required for dedifferentiation of osteosarcoma cell line. Cell Biol Int. 2016; 41(3):267-275. DOI: 10.1002/cbin.10721. View

Yang Z, Wa Q, Lu C, Pan W, Lu Z, Ao J . miR‑328‑3p enhances the radiosensitivity of osteosarcoma and regulates apoptosis and cell viability via H2AX. Oncol Rep. 2017; 39(2):545-553. PMC: 5783622. DOI: 10.3892/or.2017.6112. View

Lian D, Wang Z, Liu N . MicroRNA-1908 is a biomarker for poor prognosis in human osteosarcoma. Eur Rev Med Pharmacol Sci. 2016; 20(7):1258-62. View

Smeland S, Bielack S, Whelan J, Bernstein M, Hogendoorn P, Krailo M . Survival and prognosis with osteosarcoma: outcomes in more than 2000 patients in the EURAMOS-1 (European and American Osteosarcoma Study) cohort. Eur J Cancer. 2019; 109:36-50. PMC: 6506906. DOI: 10.1016/j.ejca.2018.11.027. View

Liu W, Zhao Z, Shi L, Yuan W . Tissue microRNA-126 expression level predicts outcome in human osteosarcoma. Diagn Pathol. 2015; 10:116. PMC: 4509614. DOI: 10.1186/s13000-015-0329-6. View

10.

Zhang H, Guo X, Feng X, Wang T, Hu Z, Que X . MiRNA-543 promotes osteosarcoma cell proliferation and glycolysis by partially suppressing PRMT9 and stabilizing HIF-1α protein. Oncotarget. 2016; 8(2):2342-2355. PMC: 5356804. DOI: 10.18632/oncotarget.13672. View

11.

Xu E, Zhao J, Ma J, Wang C, Zhang C, Jiang H . miR-146b-5p promotes invasion and metastasis contributing to chemoresistance in osteosarcoma by targeting zinc and ring finger 3. Oncol Rep. 2015; 35(1):275-83. DOI: 10.3892/or.2015.4393. View

12.

Tang W, Wang W, Zhao Y, Zhao Z . MicroRNA-874 inhibits cell proliferation and invasion by targeting cyclin-dependent kinase 9 in osteosarcoma. Oncol Lett. 2018; 15(5):7649-7654. PMC: 5920401. DOI: 10.3892/ol.2018.8294. View

13.

Sun X, Dai G, Yu L, Hu Q, Chen J, Guo W . miR-143-3p inhibits the proliferation, migration and invasion in osteosarcoma by targeting FOSL2. Sci Rep. 2018; 8(1):606. PMC: 5766605. DOI: 10.1038/s41598-017-18739-3. View

14.

Chang J, Wang W, Li Y, Hu S, Yao M, Cui X . Chinese Herbal Medicine for Osteosarcoma in the Mouse: A Systematic Review and Meta-Analysis. Chin J Integr Med. 2018; 25(5):370-377. DOI: 10.1007/s11655-018-2565-6. View

15.

Yin Z, Ding H, He E, Chen J, Li M . Up-regulation of microRNA-491-5p suppresses cell proliferation and promotes apoptosis by targeting FOXP4 in human osteosarcoma. Cell Prolif. 2016; 50(1). PMC: 6529106. DOI: 10.1111/cpr.12308. View

16.

Li Z, Li Y, Wang N, Yang L, Zhao W, Zeng X . miR-130b targets NKD2 and regulates the Wnt signaling to promote proliferation and inhibit apoptosis in osteosarcoma cells. Biochem Biophys Res Commun. 2016; 471(4):479-85. DOI: 10.1016/j.bbrc.2016.02.050. View

17.

Zhang C, Song G, Ye W, Xu B . MicroRNA-302a inhibits osteosarcoma cell migration and invasion by directly targeting IGF-1R. Oncol Lett. 2018; 15(4):5577-5583. PMC: 5858113. DOI: 10.3892/ol.2018.8049. View

18.

Wang Z, Zheng C, Jiang K, He J, Cao X, Wu S . MicroRNA-503 suppresses cell proliferation and invasion in osteosarcoma via targeting insulin-like growth factor 1 receptor. Exp Ther Med. 2017; 14(2):1547-1553. PMC: 5526065. DOI: 10.3892/etm.2017.4648. View

19.

Zhang L, Lyer A, Yang X, Kobayashi E, Guo Y, Mankin H . Polymeric nanoparticle-based delivery of microRNA-199a-3p inhibits proliferation and growth of osteosarcoma cells. Int J Nanomedicine. 2015; 10:2913-24. PMC: 4404938. DOI: 10.2147/IJN.S79143. View

20.

Anderson M . Update on Survival in Osteosarcoma. Orthop Clin North Am. 2015; 47(1):283-92. DOI: 10.1016/j.ocl.2015.08.022. View