Research Progress on the Anti-Cancer Molecular Mechanisms of Huaier

Overview

Journal Onco Targets Ther

Publisher Dove Medical Press

Specialty Oncology

Date 2020 Dec 18

PMID 33335400

Citations 11

Authors

Tongtong Qi

Yonghong Dong

Zili Gao

Jun Xu

Affiliations

Soon will be listed here.

Abstract

Huaier (), a Chinese traditional herb of medicine, has demonstrated promising curative effects in clinical treatment for various tumors. There are documented experiments showing the biological functions of Huaier with its antineoplastic molecular mechanisms: restraining proliferation and metastasis, arresting cell cycle, inducing apoptosis, pyrosis, and autophagy, anti-intratumoral angiogenesis, attenuating characteristics of tumor stem-like cells, interfering with the function of the tumor-related immune system, reversing drug resistance, and enhancing the sensitivity to chemotherapeutic drugs, etc. In addition, studies suggest that non-coding RNA (ncRNA) acts a pivotal part in cancer occurrence and development, and demonstrates that Huaier adjusts the performance of certain lncRNA (long non-coding RNA) and proceeds to affect the microRNA and its target genes, rendering an anti-tumor effect. Huaier also modulates the expression of lncRNA to attenuate the activity of ncRNA-sponged microRNA and then inhibits the expression of downstream target genes. We summarize and illustrate the experimentally confirmed anti-cancer molecular mechanisms of Huaier, to inspire new ideas for researchers in relevant fields.

Citing Articles

Immunomodulatory effects of Huaier granule in cancer therapy: a meta-analysis of randomized controlled trials.

Zang Y, Qiu Y, Sun Y, Fan Y Eur J Med Res. 2024; 29(1):467.

PMID: 39342351 PMC: 11438288. DOI: 10.1186/s40001-024-02060-7.

Huaier inhibits autophagy and promotes apoptosis in T-cell acute lymphoblastic leukemia by down-regulating SIRT1.

Qin X, Chen X, Wang F, Zhong F, Zeng Y, Liu W Heliyon. 2024; 10(17):e37313.

PMID: 39286166 PMC: 11402646. DOI: 10.1016/j.heliyon.2024.e37313.

Long-term oral administration of Huaier granules improves survival outcomes in hepatocellular carcinoma patients within Milan criteria following microwave ablation: a propensity score matching and stabilized inverse probability weighting analysis.

Xie K, Ma M, Xu F Front Pharmacol. 2024; 15:1336347.

PMID: 38774215 PMC: 11106438. DOI: 10.3389/fphar.2024.1336347.

Huaier suppresses cell viability, migration and invasion in human non-small cell lung cancer via lncRNA DLEU2/miR-212-5p/ELF3 axis.

Wu T, Liu S, Chen W, Zhao D, Lu Z Int J Med Sci. 2024; 21(2):319-331.

PMID: 38169645 PMC: 10758155. DOI: 10.7150/ijms.89308.

Immunoregulatory effects of Huaier (Trametes robiniophila Murr) and relevant clinical applications.

Long H, Wu Z Front Immunol. 2023; 14:1147098.

PMID: 37449208 PMC: 10337589. DOI: 10.3389/fimmu.2023.1147098.

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