Metabolomics Profiling and Diagnosis Biomarkers Searching for Drug-Induced Liver Injury Implicated to : A Cross-Sectional Cohort Study

Overview

Journal Front Med (Lausanne)

Specialty General Medicine

Date 2020 Dec 17

PMID 33330552

Citations 9

Authors

Ying Huang

Xu Zhao

Zi-Teng Zhang

Shuai-Shuai Chen

Shan-Shan Li

Zhuo Shi

Jing Jing

Ang Huang

Yu-Ming Guo

Zhao-Fang Bai

Zheng-Sheng Zou

Xiao-He Xiao

Jia-Bo Wang

Ming Niu

Affiliations

Soon will be listed here.

Abstract

The diagnosis of drug-induced liver injury (DILI) remains a challenge and the cases of Thunb. (PM) induced DILI (PM-DILI) have received much attention This study aimed to identify a simple and high-efficiency approach to PM-DILI diagnosis via metabolomics analysis. Plasma metabolites in 13 PM-DILI patients were profiled by liquid chromatography along with high-resolution mass spectrometry. Meanwhile, the metabolic characteristics of the PM-DILI were compared with that of autoimmune hepatitis (AIH), hepatitis B (HBV), and healthy volunteers. Twenty-four metabolites were identified to present significantly different levels in PM-DILI patients compared with HBV and AIH groups. These metabolites were enriched into glucose, amino acids, and sphingolipids metabolisms. Among these essential metabolites, the ratios of P-cresol sulfate vs. phenylalanine and inosine vs. bilirubin were further selected using a stepwise decision tree to construct a classification model in order to differentiate PM-DILI from HBV and AIH. The model was highly effective with sensitivity of 92.3% and specificity of 88.9%. This study presents an integrated view of the metabolic features of PM-DILI induced by herbal medicine, and the four-metabolite decision tree technique imparts a potent tool in clinical diagnosis.

Citing Articles

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Mechanism of Metabolic Response to Hepatectomy by Integrated Analysis of Gut Microbiota, Metabolomics, and Proteomics.

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Tandem mass tag-based quantitative proteomic profiling identifies candidate serum biomarkers of drug-induced liver injury in humans.

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The Metabolite P-Cresol Sulfate Relieves Inflammation of Primary Biliary Cholangitis by Regulating Kupffer Cells.

Fu H, Xu J, Ai X, Dang F, Tan X, Yu H Cells. 2022; 11(23).

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