Radon-The Element of Risk. The Impact of Radon Exposure on Human Health

Overview

Journal Toxics

Date 2020 Dec 17

PMID 33327615

Citations 7

Authors

Anna Grzywa-Celinska

Adam Krusinski

Jadwiga Mazur

Katarzyna Szewczyk

Krzysztof Kozak

Affiliations

Soon will be listed here.

Abstract

Lung cancer is a heterogeneous group of diseases with multifactorial aetiology. Smoking has been undeniably recognized as the main aetiological factor in lung cancer, but it should be emphasized that it is not the only factor. It is worth noting that a number of nonsmokers also develop this disease. Radon exposure is the second greatest risk factor for lung cancer among smokers-after smoking-and the first one for nonsmokers. The knowledge about this element amongst specialist oncologists and pulmonologists seems to be very superficial. We discuss the impact of radon on human health, with particular emphasis on respiratory diseases, including lung cancer. A better understanding of the problem will increase the chance of reducing the impact of radon exposure on public health and may contribute to more effective prevention of a number of lung diseases.

Citing Articles

Systematic Review and Meta-Analysis of Inflammatory Biomarkers in Individuals Exposed to Radon.

Lesbek A, Omori Y, Bakhtin M, Kazymbet P, Tokonami S, Altaeva N Biomedicines. 2025; 13(2).

PMID: 40002912 PMC: 11853710. DOI: 10.3390/biomedicines13020499.

Serum biomarkers associated with health impacts of high residential radon exposure: a metabolomic pilot study.

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Serum Metabolomics Study to Screen Potential Biomarkers of Lung Cancer Risk in High Natural Background Radiation Areas of Thailand: A Pilot Study.

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Indoor radon exposure: A systematic review of radon-induced health risks and evidence quality using GRADE approach.

Mphaga K, Utembe W, Mbonane T, Rathebe P Heliyon. 2024; 10(23):e40439.

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Short-Term vs. Long-Term: A Critical Review of Indoor Radon Measurement Techniques.

Mphaga K, Mbonane T, Utembe W, Rathebe P Sensors (Basel). 2024; 24(14).

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References

Beresford N, Scott E, Copplestone D . Field effects studies in the Chernobyl Exclusion Zone: Lessons to be learnt. J Environ Radioact. 2019; 211:105893. DOI: 10.1016/j.jenvrad.2019.01.005. View

Grammaticos P, Giannoula E, Fountos G . Acute radiation syndrome and chronic radiation syndrome. Hell J Nucl Med. 2013; 16(1):56-9. View

Lantz P, Mendez D, Philbert M . Radon, smoking, and lung cancer: the need to refocus radon control policy. Am J Public Health. 2013; 103(3):443-7. PMC: 3673501. DOI: 10.2105/AJPH.2012.300926. View

Torres-Duran M, Ruano-Ravina A, Parente-Lamelas I, Leiro-Fernandez V, Abal-Arca J, Montero-Martinez C . Residential radon and lung cancer characteristics in never smokers. Int J Radiat Biol. 2015; 91(8):605-10. DOI: 10.3109/09553002.2015.1047985. View

Kendall G, Smith T . Doses from radon and its decay products to children. J Radiol Prot. 2005; 25(3):241-56. DOI: 10.1088/0952-4746/25/3/002. View

Liu X, Wang X, Tong J . Radon-induced alterations in p53-mediated energy metabolism of malignantly transformed human bronchial epithelial cells. J Toxicol Environ Health A. 2016; 79(9-10):436-41. DOI: 10.1080/15287394.2016.1176629. View

Vienneau D, de Hoogh K, Hauri D, Vicedo-Cabrera A, Schindler C, Huss A . Effects of Radon and UV Exposure on Skin Cancer Mortality in Switzerland. Environ Health Perspect. 2017; 125(6):067009. PMC: 5744747. DOI: 10.1289/EHP825. View

He J, Foreman M, Shumansky K, Zhang X, Akhabir L, Sin D . Associations of IL6 polymorphisms with lung function decline and COPD. Thorax. 2009; 64(8):698-704. PMC: 2859187. DOI: 10.1136/thx.2008.111278. View

Brauner E, Andersen Z, Andersen C, Pedersen C, Gravesen P, Ulbak K . Residential radon and brain tumour incidence in a Danish cohort. PLoS One. 2013; 8(9):e74435. PMC: 3774631. DOI: 10.1371/journal.pone.0074435. View

10.

Corrales L, Rosell R, Cardona A, Martin C, Zatarain-Barron Z, Arrieta O . Lung cancer in never smokers: The role of different risk factors other than tobacco smoking. Crit Rev Oncol Hematol. 2020; 148:102895. DOI: 10.1016/j.critrevonc.2020.102895. View

11.

Tangen J, Jaworska A . Treatment of acute radiation injuries. Tidsskr Nor Laegeforen. 2013; 133(20):2164-6. DOI: 10.4045/tidsskr.13.0218. View

12.

Evrard A, Hemon D, Billon S, Laurier D, Jougla E, Tirmarche M . Childhood leukemia incidence and exposure to indoor radon, terrestrial and cosmic gamma radiation. Health Phys. 2006; 90(6):569-79. DOI: 10.1097/01.HP.0000198787.93305.35. View

13.

Skowronek J, Zemla B . Epidemiology of lung and larynx cancers in coal mines in Upper Silesia--preliminary results. Health Phys. 2003; 85(3):365-70. DOI: 10.1097/00004032-200309000-00013. View

14.

Kohli S, Noorlind Brage H, Lofman O . Childhood leukaemia in areas with different radon levels: a spatial and temporal analysis using GIS. J Epidemiol Community Health. 2000; 54(11):822-6. PMC: 1731593. DOI: 10.1136/jech.54.11.822. View

15.

Balashazy I, Hofmann W . Quantification of local deposition patterns of inhaled radon decay products in human bronchial airway bifurcations. Health Phys. 2000; 78(2):147-58. DOI: 10.1097/00004032-200002000-00004. View

16.

Kumar A, Chauhan R, Joshi M, Sahoo B . Modeling of indoor radon concentration from radon exhalation rates of building materials and validation through measurements. J Environ Radioact. 2013; 127:50-5. DOI: 10.1016/j.jenvrad.2013.10.004. View

17.

Prise K, Pinto M, NEWMAN H, Michael B . A review of studies of ionizing radiation-induced double-strand break clustering. Radiat Res. 2001; 156(5 Pt 2):572-6. DOI: 10.1667/0033-7587(2001)156[0572:arosoi]2.0.co;2. View

18.

Finne I, Kolstad T, Larsson M, Olsen B, Prendergast J, Rudjord A . Significant reduction in indoor radon in newly built houses. J Environ Radioact. 2018; 196:259-263. DOI: 10.1016/j.jenvrad.2018.01.013. View

19.

Thabayneh K . Measurement of (222)Rn concentration levels in drinking water and the associated health effects in the Southern part of West Bank - Palestine. Appl Radiat Isot. 2015; 103:48-53. DOI: 10.1016/j.apradiso.2015.05.007. View

20.

Maggiore G, De Filippis G, Totaro T, Tamborino B, Idolo A, Serio F . Evaluation of radon exposure risk and lung cancer incidence/mortality in South-eastern Italy. J Prev Med Hyg. 2020; 61(1):E31-E38. PMC: 7225648. DOI: 10.15167/2421-4248/jpmh2020.61.1.1343. View