Multiple Renal Infarctions in a Patient Caused by Granulomatosis with Polyangiitis

Overview

Journal J Int Med Res

Publisher Sage Publications

Specialty General Medicine

Date 2020 Dec 16

PMID 33322993

Citations 2

Authors

Xiao Lu

ChengYing Yuan

Rongshan Li

Affiliations

Soon will be listed here.

Abstract

Granulomatosis with polyangiitis (GPA) is a small-vessel vasculitis that is highly associated with anti-neutrophil cytoplasmic antibodies. GPA carries an increased risk of organ infarction, but renal infarction is rare. We herein describe a case of multiple renal infarctions caused by GPA. A 66-year-old man presented with hearing loss, nasal discharge, fatigue, and weight loss for several months. Cross-sectional contrast-enhanced computed tomography images revealed multiple low-attenuation areas in both kidneys. He subsequently developed fever and impaired renal function. Blood serum was positive for cytoplasmic anti-neutrophil cytoplasmic antibody and a renal biopsy showed granulomatous necrotizing vasculitis. He was diagnosed with GPA and treated with high-dose corticosteroids, plasma exchange, and cyclophosphamide. The patient ultimately entered clinical remission.

Citing Articles

Renal Embolism Associated with Foramen Ovale Coexisting Acute Pulmonary Embolism.

He Y, Xiao Y, Chen Y, Li Z Case Rep Pulmonol. 2023; 2023:6670080.

PMID: 38094037 PMC: 10719030. DOI: 10.1155/2023/6670080.

Granulomatosis With Polyangiitis Complicated by Diffuse Alveolar Hemorrhage, Splenic Infarction and Stroke.

Zhang K, Salih Makawi M, Saab O, Elshakh H, Trivedi P Cureus. 2022; 14(10):e30102.

PMID: 36381831 PMC: 9643011. DOI: 10.7759/cureus.30102.

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