Unusual Faces of Bladder Cancer

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2020 Dec 16

PMID 33321728

Citations 6

Authors

Claudia Manini

Jose I Lopez

Affiliations

Soon will be listed here.

Abstract

The overwhelming majority of bladder cancers are transitional cell carcinomas. Albeit mostly monotonous, carcinomas in the bladder may occasionally display a broad spectrum of histological features that should be recognized by pathologists because some of them represent a diagnostic problem and/or lead prognostic implications. Sometimes these features are focal in the context of conventional transitional cell carcinomas, but some others are generalized across the tumor making its recognition a challenge. For practical purposes, the review distributes the morphologic spectrum of changes in architecture and cytology. Thus, nested and large nested, micropapillary, myxoid stroma, small tubules and adenoma nephrogenic-like, microcystic, verrucous, and diffuse lymphoepithelioma-like, on one hand, and plasmacytoid, signet ring, basaloid-squamous, yolk-sac, trophoblastic, rhabdoid, lipid/lipoblastic, giant, clear, eosinophilic (oncocytoid), and sarcomatoid, on the other, are revisited. Key histological and immunohistochemical features useful in the differential diagnosis are mentioned. In selected cases, molecular data associated with the diagnosis, prognosis, and/or treatment are also included.

Citing Articles

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Inflammatory Myofibroblastic Tumour of the Urinary Bladder in a Middle-Aged Man-A Case Report of an Unusual Localization of a Rare Tumour.

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Outcomes of poorly differentiated and plasmacytoid variant bladder urothelial carcinoma.

Lockhart K, King S, Grant A, McLeod N, Tiu A BJUI Compass. 2022; 3(1):62-67.

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Sarcomatoid Urothelial Carcinoma With Myxoid Stroma: A Case Report and Diagnostic Approach.

Taseer R, Ahmed T Cureus. 2021; 13(3):e14007.

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Mimickers of Urothelial Carcinoma and the Approach to Differential Diagnosis.

Manini C, Angulo J, Lopez J Clin Pract. 2021; 11(1):110-123.

PMID: 33668963 PMC: 7931042. DOI: 10.3390/clinpract11010017.

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