Antimicrobial Susceptibility of Isolates from Veal, Dairy and Beef Herds

Overview

Journal Antibiotics (Basel)

Specialty Pharmacology

Date 2020 Dec 15

PMID 33316982

Citations 11

Authors

Jade Bokma

Linde Gille

Koen De Bleecker

Jozefien Callens

Freddy Haesebrouck

Bart Pardon

Filip Boyen

Affiliations

Soon will be listed here.

Abstract

is an important pathogen causing mostly pneumonia in calves and mastitis in dairy cattle. In the absence of an effective vaccine, antimicrobial therapy remains the main control measure. Antimicrobial use in veal calves is substantially higher than in conventional herds, but whether veal calves also harbor more resistant strains is currently unknown. Therefore, we compared antimicrobial susceptibility test results of isolates from different cattle sectors and genomic clusters. The minimum inhibitory concentration of nine antimicrobials was determined for 141 Belgian isolates (29 dairy, 69 beef, 12 mixed, 31 veal farms), and was used to estimate the epidemiological cut-off. Acquired resistance was frequently observed for the macrolides, while no acquired resistance to oxytetracycline and doxycycline, minimal acquired resistance to florfenicol and tiamulin, and a limited acquired resistance to enrofloxacin was seen. isolates from beef cattle or genomic cluster III had higher odds of being gamithromycin-resistant than those from dairy cattle or genomic clusters IV and V. In this study, no cattle industry could be identified as source of resistant strains. A single guideline for antimicrobial use for infections, with a small remark for gamithromycin, is likely sufficient.

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