The Efficacy of Treating Patients with Non-metastatic Gastric Linitis Plastica Using Surgery with Chemotherapy And/or Radiotherapy

Overview

Journal Ann Transl Med

Publisher AME Publishing Company

Date 2020 Dec 14

PMID 33313178

Citations 1

Authors

Xueru Song

Yan Shi

Tao Shi

Baorui Liu

Jia Wei

Jiping Wang

Affiliations

Soon will be listed here.

Abstract

Background: To explore the efficacy of treatment strategies for non-metastatic gastric linitis plastica (GLP).

Methods: Patients with non-metastatic GLP from 2004 to 2014 were identified from the National Cancer Database (NCDB). We compared overall survival (OS) of those patients who received different treatments, including surgery alone, a combination of surgery with chemotherapy and/or radiotherapy (S + C/R), chemotherapy and/or radiotherapy (C/R), and no treatment.

Results: The cohort included 474 patients with non-metastatic GLP. Overall, the median survival was significantly different among four groups (13.90 months in S + C/R, 8.38 months in surgery alone, 8.94 months in C/R and 2.50 months in no treatment). Then, we compared the efficacy of surgery alone and surgery with postoperative chemotherapy and/or radiotherapy (S + post C/R). When the tumor size was greater than 8 cm in stage III patients, S + post C/R was associated with a better survival benefit than surgery alone. S + post C/R also conferred an obvious survival advantage compared to surgery alone for R0 patients with positive lymph nodes and patients with positive margins.

Conclusions: Surgery plays the fundamental role in improving the OS of patients with non-metastatic GLP. S + post C/R would benefit patients in stage III with large-sized tumors (>8 cm), patients with negative margins and positive lymph nodes, and/or patients with positive margins.

Citing Articles

The Genomic Signatures of Linitis Plastica Signal the Entrance into a New Era: Novel Approaches for Diagnosis and Treatment.

Christodoulidis G, Koumarelas K, Kouliou M, Samara M, Thodou E, Zacharoulis D Int J Mol Sci. 2023; 24(19).

PMID: 37834127 PMC: 10572839. DOI: 10.3390/ijms241914680.

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