The Use Of Dermal Regeneration Templates For Primary Burns Surgery In A UK Regional Burns Centre

Overview

Journal Ann Burns Fire Disasters

Date 2020 Dec 11

PMID 33304216

Citations 12

Authors

G S A Phillips

M Nizamoglu

A Wakure

D Barnes

N El-Muttardi

P Dziewulski

Affiliations

Soon will be listed here.

Abstract

The gold standard of treatment for major burns is early burn excision and autografting. In major burns this is complicated by a lack of donor site availability. Another challenge after burn injury is achieving optimal cosmetic and functional outcomes. Dermal regeneration templates (DRT) are biomatrices that help to address these problems. Within our centre the most commonly used are two-stage Integra® and single-stage Matriderm®. We review the use and outcomes of DRT in primary burns reconstruction within our regional burns centre. All patients undergoing primary burn reconstruction using Integra® (n=59) or Matriderm® (n=35) over a 13-year period were included. Integra® was used in patients with significantly larger burns (20.4% TBSA vs 1.7% TBSA). Comparable levels of graft take were seen in both groups. Major infections were significantly higher in the Integra® group (11/35 compared to 3/59). There was no significant difference in haematoma development, hypertrophic scarring or the need for secondary reconstructive surgery. Burn contractures developed in 15 patients treated with Matriderm® and 21 with Integra®. DRT have been used safely and effectively and have played an increasingly important role in our service over the last 13 years. Integra® is used primarily in large burns with limited donor sites and Matriderm® in smaller burns in cosmetically sensitive areas.

Citing Articles

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Indications for the use of dermal substitutes in patients with acute burns and in reconstructive surgery after burns: A systematic review.

van den Bosch A, Verwilligen R, Pijpe A, Jansen L, van der Vlies C, van Eck M Wound Repair Regen. 2024; 33(1):e13248.

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Efficacy and Complications Associated with Acellular Dermal Substitute Use in the Treatment of Acute Burns: A Systematic Review and Meta-Analysis.

Press I, Moiemen N, Ahmed Z Eur Burn J. 2024; 4(4):548-562.

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Biodegradable Temporising matrix in the reconstruction of complex wounds: A systematic review and meta-analysis.

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Dermal Regeneration Template in the Management and Reconstruction of Burn Injuries and Complex Wounds: A Review.

Gupta S, Moiemen N, Fischer J, Attinger C, Jeschke M, Taupin P Plast Reconstr Surg Glob Open. 2024; 12(3):e5674.

PMID: 38510326 PMC: 10954069. DOI: 10.1097/GOX.0000000000005674.

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