Forkhead Transcription Factors in Health and Disease

Overview

Journal Trends Genet

Specialty Genetics

Date 2020 Dec 11

PMID 33303287

Citations 42

Authors

Laetitia Herman

Anne-Laure Todeschini

Reiner A Veitia

Affiliations

Soon will be listed here.

Abstract

Forkhead box (FOX) proteins belong to an evolutionarily conserved family of transcription factors that has evolved by gene/genome duplication. FOX family members have undergone sequence and regulatory diversification. However, they have retained some degree of functional redundancy, in addition to playing specific roles, both during development and in the adult. Genetic alterations or misregulation of FOX genes underlie human genetic diseases, cancer, and/or aging. In this review, we provide an updated overview of the main characteristics of the members of this family, in terms of breadth of expression, protein domain composition, evolution, and function.

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