Extracellular Vesicles Released from Irradiated Neonatal Mouse Cheek Tissue Increased Cell Survival After Radiation

Overview

Journal J Radiat Res

Publisher Oxford University Press

Specialties Environmental Health
Oncology
Radiology

Date 2020 Dec 10

PMID 33302296

Citations 3

Authors

Kentaro Ariyoshi

Yota Hiroyama

Naoya Fujiwara

Tomisato Miura

Kosuke Kasai

Akifumi Nakata

Yohei Fujishima

Valerie Swee Ting Goh

Mitsuaki A Yoshida

Affiliations

Soon will be listed here.

Abstract

Alopecia is one of the common symptoms after high-dose radiation exposure. In our experiments, neonatal mice that received 7 Gy X-ray exhibited defects in overall hair growth, except for their cheeks. This phenomenon might suggest that some substances were secreted and prevented hair follicle loss in the infant tissues around their cheeks after radiation damage. In this study, we focused on exosome-like vesicles (ELV) secreted from cheek skin tissues and back skin tissues, as control, and examined their radiation protective effects on mouse fibroblast cell lines. We observed that ELV from irradiated cheek skin showed protective effects from radiation. Our results suggest that ELV from radiation-exposed cheek skin tissue is one of the secreted factors that prevent hair follicle loss after high-dose radiation.

Citing Articles

Clinical applications of exosomes in cosmetic dermatology.

Bai G, Truong T, Pathak G, Benoit L, Rao B Skin Health Dis. 2024; 4(6):e348.

PMID: 39624733 PMC: 11608875. DOI: 10.1002/ski2.348.

Exosome-like vesicles released from ob/ob mouse adipose tissue enhance cell survival of cells with radiation-induced genomic instability.

Ariyoshi K, Fujishima Y, Goh V, Nakata A, Kasai K, Yoshida M J Radiat Res. 2023; 64(2):352-357.

PMID: 36680768 PMC: 10036088. DOI: 10.1093/jrr/rrac102.

The Footprint of Exosomes in the Radiation-Induced Bystander Effects.

Jokar S, Marques I, Khazaei S, Martins-Marques T, Girao H, Laranjo M Bioengineering (Basel). 2022; 9(6).

PMID: 35735486 PMC: 9220715. DOI: 10.3390/bioengineering9060243.

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