Adaptive Response of Resistant Cancer Cells to Chemotherapy

Overview

Journal Cancer Biol Med

Specialty Oncology

Date 2020 Dec 10

PMID 33299639

Citations 20

Authors

Yi-Jye Chern

Isabella T Tai

Affiliations

Soon will be listed here.

Abstract

Despite advances in cancer therapeutics and the integration of personalized medicine, the development of chemoresistance in many patients remains a significant contributing factor to cancer mortality. Upon treatment with chemotherapeutics, the disruption of homeostasis in cancer cells triggers the adaptive response which has emerged as a key resistance mechanism. In this review, we summarize the mechanistic studies investigating the three major components of the adaptive response, autophagy, endoplasmic reticulum (ER) stress signaling, and senescence, in response to cancer chemotherapy. We will discuss the development of potential cancer therapeutic strategies in the context of these adaptive resistance mechanisms, with the goal of stimulating research that may facilitate the development of effective cancer therapy.

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References

Wang N, Wang Z, Peng C, You J, Shen J, Han S . Dietary compound isoliquiritigenin targets GRP78 to chemosensitize breast cancer stem cells via β-catenin/ABCG2 signaling. Carcinogenesis. 2014; 35(11):2544-54. DOI: 10.1093/carcin/bgu187. View

Strohecker A, Guo J, Karsli-Uzunbas G, Price S, Chen G, Mathew R . Autophagy sustains mitochondrial glutamine metabolism and growth of BrafV600E-driven lung tumors. Cancer Discov. 2013; 3(11):1272-85. PMC: 3823822. DOI: 10.1158/2159-8290.CD-13-0397. View

Chiu C, Lee L, Li Y, Chen Y, Lu Y, Li Y . Grp78 as a therapeutic target for refractory head-neck cancer with CD24(-)CD44(+) stemness phenotype. Cancer Gene Ther. 2013; 20(11):606-15. DOI: 10.1038/cgt.2013.64. View

Takahashi H, Inoue J, Sakaguchi K, Takagi M, Mizutani S, Inazawa J . Autophagy is required for cell survival under L-asparaginase-induced metabolic stress in acute lymphoblastic leukemia cells. Oncogene. 2017; 36(30):4267-4276. PMC: 5537607. DOI: 10.1038/onc.2017.59. View

Baylot V, Andrieu C, Katsogiannou M, Taieb D, Garcia S, Giusiano S . OGX-427 inhibits tumor progression and enhances gemcitabine chemotherapy in pancreatic cancer. Cell Death Dis. 2011; 2:e221. PMC: 3219088. DOI: 10.1038/cddis.2011.104. View

Huang J, Yang Y, Fang F, Liu K . MALAT1 modulates the autophagy of retinoblastoma cell through miR-124-mediated stx17 regulation. J Cell Biochem. 2017; 119(5):3853-3863. DOI: 10.1002/jcb.26464. View

Yang A, Fan F, Camp E, Van Buren G, Liu W, Somcio R . Chronic oxaliplatin resistance induces epithelial-to-mesenchymal transition in colorectal cancer cell lines. Clin Cancer Res. 2006; 12(14 Pt 1):4147-53. DOI: 10.1158/1078-0432.CCR-06-0038. View

Baumeister P, Dong D, Fu Y, Lee A . Transcriptional induction of GRP78/BiP by histone deacetylase inhibitors and resistance to histone deacetylase inhibitor-induced apoptosis. Mol Cancer Ther. 2009; 8(5):1086-94. PMC: 2889001. DOI: 10.1158/1535-7163.MCT-08-1166. View

Whitesell L, Lindquist S . HSP90 and the chaperoning of cancer. Nat Rev Cancer. 2005; 5(10):761-72. DOI: 10.1038/nrc1716. View

10.

Yin X, Dewille J, Hai T . A potential dichotomous role of ATF3, an adaptive-response gene, in cancer development. Oncogene. 2007; 27(15):2118-27. DOI: 10.1038/sj.onc.1210861. View

11.

Kelber J, Panopoulos A, Shani G, Booker E, Belmonte J, Vale W . Blockade of Cripto binding to cell surface GRP78 inhibits oncogenic Cripto signaling via MAPK/PI3K and Smad2/3 pathways. Oncogene. 2009; 28(24):2324-36. PMC: 2749668. DOI: 10.1038/onc.2009.97. View

12.

Nakasone E, Askautrud H, Kees T, Park J, Plaks V, Ewald A . Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance. Cancer Cell. 2012; 21(4):488-503. PMC: 3332002. DOI: 10.1016/j.ccr.2012.02.017. View

13.

Zhou H, Zhang Y, Fu Y, Chan L, Lee A . Novel mechanism of anti-apoptotic function of 78-kDa glucose-regulated protein (GRP78): endocrine resistance factor in breast cancer, through release of B-cell lymphoma 2 (BCL-2) from BCL-2-interacting killer (BIK). J Biol Chem. 2011; 286(29):25687-96. PMC: 3138298. DOI: 10.1074/jbc.M110.212944. View

14.

Mani S, Guo W, Liao M, Eaton E, Ayyanan A, Zhou A . The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell. 2008; 133(4):704-15. PMC: 2728032. DOI: 10.1016/j.cell.2008.03.027. View

15.

Chern Y, Wong J, Cheng G, Yu A, Yin Y, Schaeffer D . The interaction between SPARC and GRP78 interferes with ER stress signaling and potentiates apoptosis via PERK/eIF2α and IRE1α/XBP-1 in colorectal cancer. Cell Death Dis. 2019; 10(7):504. PMC: 6594974. DOI: 10.1038/s41419-019-1687-x. View

16.

Xiong H, Ni Z, Jiang S, Li X, He J, Gong W . LncRNA HULC triggers autophagy via stabilizing Sirt1 and attenuates the chemosensitivity of HCC cells. Oncogene. 2017; 36(25):3528-3540. DOI: 10.1038/onc.2016.521. View

17.

Coppe J, Desprez P, Krtolica A, Campisi J . The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol. 2010; 5:99-118. PMC: 4166495. DOI: 10.1146/annurev-pathol-121808-102144. View

18.

Calderwood S, Khaleque M, Sawyer D, Ciocca D . Heat shock proteins in cancer: chaperones of tumorigenesis. Trends Biochem Sci. 2006; 31(3):164-72. DOI: 10.1016/j.tibs.2006.01.006. View

19.

Uckun F, Qazi S, Ozer Z, Garner A, Pitt J, Ma H . Inducing apoptosis in chemotherapy-resistant B-lineage acute lymphoblastic leukaemia cells by targeting HSPA5, a master regulator of the anti-apoptotic unfolded protein response signalling network. Br J Haematol. 2011; 153(6):741-52. DOI: 10.1111/j.1365-2141.2011.08671.x. View

20.

Azad A, Zoubeidi A, Gleave M, Chi K . Targeting heat shock proteins in metastatic castration-resistant prostate cancer. Nat Rev Urol. 2014; 12(1):26-36. DOI: 10.1038/nrurol.2014.320. View