The Blood Cerebrospinal Fluid Barrier Orchestrates Immunosurveillance, Immunoprotection, and Immunopathology in the Central Nervous System

Overview

Journal BMB Rep

Specialties Biochemistry
Molecular Biology

Date 2020 Dec 10

PMID 33298242

Citations 11

Authors

Maria Ayub

Hee Kyung Jin

Jae-Sung Bae

Affiliations

Soon will be listed here.

Abstract

Once characterized as an immune privileged area, recent scientific advances have demonstrated that the central nervous system (CNS) is both immunologically active and a specialized site. The anatomical and cellular features of the brain barriers, the glia limitans, and other superficial coverings of the CNS endow the brain with specificity for immune cell entry and other macro- and micro-elements to the brain. Cellular trafficking via barriers comprised of tightly junctioned non-fenestrated endothelium or tightly regulated fenestrated epithelium results in different phenotypic and cellular changes in the brain, that is, inflammatory versus regulatory changes. Based on emerging evidence, we described the unique ability of the blood cerebrospinal fluid barrier (BCSFB) to recruit, skew, and suppress immune cells. Additionally, we sum up the current knowledge on both cellular and molecular mechanisms governed by the choroid plexus and the cerebrospinal fluid at the BCSFB for immunosurveillance, immunoprotection, and immunopathology. [BMB Reports 2021; 54(4): 196-202].

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