Human Ros1 and Mas1 Oncogenes Located in Regions of Chromosome 6 Associated with Tumor-specific Rearrangements

Overview

Journal Oncogene Res

Specialty Cell Biology

Date 1987 Jul 1

PMID 3329713

Citations 14

Authors

M Rabin

D Birnbaum

D Young

C Birchmeier

M Wigler

F H Ruddle

Affiliations

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Abstract

Oncogenes have been implicated in tumorigenesis based on their localization to chromosomal sites associated with tumor-specific structural rearrangements. We have mapped the human ros1 (formerly mcf3) and mas1 oncogenes to the distal half of chromosome 6q, within a region frequently rearranged in malignant cells. Chromosomal mapping of these two new human transforming genes may help elucidate the involvement of the long arm of chromosome 6 in diverse tumor types.

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