Dynamic Profile of the HBeAg-anti-HBe System in Acute and Chronic Hepatitis B Virus Infection: A Clinical-laboratory Approach

Overview

Journal Mol Biol Rep

Specialty Molecular Biology

Date 2020 Dec 9

PMID 33296069

Citations 5

Authors

Roberio Amorim de Almeida Ponde

Affiliations

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Abstract

Wild-type HBV infection is followed by the blood expression of its widely known serological markers of infection, and designated as, hepatitis B virus surface antigen (HBsAg) and its antibody (anti-HBs), anti-HBc antibodies (IgM/IgG), and hepatitis B virus 'e' antigen (HBeAg) and its antibody (anti-HBe). These markers are detected as the infection develops and its kinetic behavior serves as a basis for monitoring the disorder and for diagnosing the clinical form or infection phase. Among these, the HBeAg-anti-HBe system markers demonstrate a dynamic profile whose interpretation, both in the acute or chronic HBV infection context, can offer greater difficulty to the health professionals, due to its particularities. This review offers a revisit to the markers dynamics of this system in the acute and chronic HBV infection and to the clinical and laboratory significance of its expression in these two clinical contexts.

Citing Articles

Detection of hepatitis B virus surface antigen, IgM and IgG antibodies to hepatitis B virus core antigen in the clinical classification and epidemiological surveillance of HBV infection.

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References

Higuchi T, TILLMAN W . Stress-relaxation of stretched callus strips. Influence of various solvent and solution environment on mechanoelastic properties of cornified epithelium. Arch Environ Health. 1965; 11(4):508-21. DOI: 10.1080/00039896.1965.10664251. View

Kidd-Ljunggren K, Holmberg A, Blackberg J, Lindqvist B . High levels of hepatitis B virus DNA in body fluids from chronic carriers. J Hosp Infect. 2006; 64(4):352-7. DOI: 10.1016/j.jhin.2006.06.029. View

Shih Y, Liu C . Mother-to-infant transmission of hepatitis B virus: challenges and perspectives. Hepatol Int. 2017; 11(6):481-484. DOI: 10.1007/s12072-017-9831-0. View

Ali B, Huang T, Salem H, Xie Q . Expression of hepatitis B virus genes in early embryonic cells originated from hamster ova and human spermatozoa transfected with the complete viral genome. Asian J Androl. 2006; 8(3):273-9. DOI: 10.1111/j.1745-7262.2006.00141.x. View

Indolfi G, Easterbrook P, Dusheiko G, Siberry G, Chang M, Thorne C . Hepatitis B virus infection in children and adolescents. Lancet Gastroenterol Hepatol. 2019; 4(6):466-476. DOI: 10.1016/S2468-1253(19)30042-1. View

Biswas R, Tabor E, Hsia C, Wright D, Laycock M, Fiebig E . Comparative sensitivity of HBV NATs and HBsAg assays for detection of acute HBV infection. Transfusion. 2003; 43(6):788-98. DOI: 10.1046/j.1537-2995.2003.00424.x. View

Yoshikawa A, Gotanda Y, Itabashi M, Minegishi K, Kanemitsu K, Nishioka K . HBV NAT positive [corrected] blood donors in the early and late stages of HBV infection: analyses of the window period and kinetics of HBV DNA. Vox Sang. 2005; 88(2):77-86. DOI: 10.1111/j.1423-0410.2005.00602.x. View

Schreiber G, Busch M, Kleinman S, Korelitz J . The risk of transfusion-transmitted viral infections. The Retrovirus Epidemiology Donor Study. N Engl J Med. 1996; 334(26):1685-90. DOI: 10.1056/NEJM199606273342601. View

Grant P, Busch M . Nucleic acid amplification technology methods used in blood donor screening. Transfus Med. 2002; 12(4):229-42. DOI: 10.1046/j.1365-3148.2002.00382.x. View

10.

Kleinman S, Busch M . Assessing the impact of HBV NAT on window period reduction and residual risk. J Clin Virol. 2006; 36 Suppl 1:S23-9. DOI: 10.1016/s1386-6532(06)80005-3. View

11.

Scheiblauer H, El-Nageh M, Diaz S, Nick S, Zeichhardt H, Grunert H . Performance evaluation of 70 hepatitis B virus (HBV) surface antigen (HBsAg) assays from around the world by a geographically diverse panel with an array of HBV genotypes and HBsAg subtypes. Vox Sang. 2010; 98(3 Pt 2):403-14. PMC: 2860763. DOI: 10.1111/j.1423-0410.2009.01272.x. View

12.

Liaw Y, Chu C . Hepatitis B virus infection. Lancet. 2009; 373(9663):582-92. DOI: 10.1016/S0140-6736(09)60207-5. View

13.

Sarkar N, Pal A, Das D, Saha D, Biswas A, Bandopadhayay B . Virological Characteristics of Acute Hepatitis B in Eastern India: Critical Differences with Chronic Infection. PLoS One. 2015; 10(11):e0141741. PMC: 4646492. DOI: 10.1371/journal.pone.0141741. View

14.

Inoue K, Yoshiba M, Sekiyama K, Okamoto H, Mayumi M . Clinical and molecular virological differences between fulminant hepatic failures following acute and chronic infection with hepatitis B virus. J Med Virol. 1998; 55(1):35-41. DOI: 10.1002/(sici)1096-9071(199805)55:1<35::aid-jmv7>3.0.co;2-p. View

15.

Webster G, Reignat S, Maini M, Whalley S, Ogg G, King A . Incubation phase of acute hepatitis B in man: dynamic of cellular immune mechanisms. Hepatology. 2000; 32(5):1117-24. DOI: 10.1053/jhep.2000.19324. View

16.

Tseng T, Liu C, Yang H, Su T, Wang C, Chen C . Determinants of spontaneous surface antigen loss in hepatitis B e antigen-negative patients with a low viral load. Hepatology. 2011; 55(1):68-76. DOI: 10.1002/hep.24615. View

17.

Chan H, Wong G, Tse C, Chan H, Wong V . Viral determinants of hepatitis B surface antigen seroclearance in hepatitis B e antigen-negative chronic hepatitis B patients. J Infect Dis. 2011; 204(3):408-14. DOI: 10.1093/infdis/jir283. View

18.

Yang P, Althage A, Chung J, Maier H, Wieland S, Isogawa M . Immune effectors required for hepatitis B virus clearance. Proc Natl Acad Sci U S A. 2010; 107(2):798-802. PMC: 2818933. DOI: 10.1073/pnas.0913498107. View

19.

Jeremiah Z, Idris H, Ajayi B, Ezimah A, Malah M, Baba M . Isolated anti-HBc-IgM antibody among blood donors in the semi-arid region of Nigeria. Hum Antibodies. 2011; 20(3-4):77-82. DOI: 10.3233/HAB-2011-0242. View

20.

Milich D, McLachlan A . The nucleocapsid of hepatitis B virus is both a T-cell-independent and a T-cell-dependent antigen. Science. 1986; 234(4782):1398-401. DOI: 10.1126/science.3491425. View