Aerobic Exercise and Cardiac Function of Murines Exposed to Doxorubicin: a Meta-Analysis

Overview

Journal Arq Bras Cardiol

Specialty Cardiology & Vascular Diseases

Date 2020 Dec 9

PMID 33295451

Citations 4

Authors

Mariana Inocencio Matos

Ercole da Cruz Rubini

Frederico de Oliveira Meirelles

Elirez Bezerra da Silva

Affiliations

Soon will be listed here.

Abstract

Background: Cardiotoxicity may be a consequence of treatments with doxorubicin (DOX).

Objectives: To investigate the effect of aerobic exercise on the prevention of cardiac dysfunction in murines exposed to DOX.

Method: A comprehensive search was conducted in 9 databases in December 2017. Studies that evaluated the cardiac function of murines exposed to DOX were included. The significance level adopted was 5%.

Results: In a comparison between 230 murines that underwent aerobic exercise plus DOX treatment and 222 control murines (DOX treatment only), fractional shortening showed an improvement of 5.33% in favor of the experimental group (p = 0.00001). Left ventricle developed pressure also showed an increase of 24.84 mm Hg in favor of the group of 153 murines that performed exercise in comparison to the control group of 166 murines (p = 0.00001).

Conclusion: Preclinical studies included in this meta-analysis indicated that exercise is a good nonpharmacological strategy for preserving post-DOX cardiac function.

Citing Articles

Creatine and Resistance Training: A Combined Approach to Attenuate Doxorubicin-Induced Cardiotoxicity.

Law D, Magrini M, Siedlik J, Eckerson J, Drescher K, Bredahl E Nutrients. 2023; 15(18).

PMID: 37764831 PMC: 10536171. DOI: 10.3390/nu15184048.

Physical Activity as the Best Supportive Care in Cancer: The Clinician's and the Researcher's Perspectives.

Torregrosa C, Chorin F, Ester Molina Beltran E, Neuzillet C, Cardot-Ruffino V Cancers (Basel). 2022; 14(21).

PMID: 36358820 PMC: 9655932. DOI: 10.3390/cancers14215402.

Irisin ameliorates doxorubicin-induced cardiac perivascular fibrosis through inhibiting endothelial-to-mesenchymal transition by regulating ROS accumulation and autophagy disorder in endothelial cells.

Pan J, Zhang H, Lin H, Gao L, Zhang H, Zhang J Redox Biol. 2021; 46:102120.

PMID: 34479089 PMC: 8413906. DOI: 10.1016/j.redox.2021.102120.

Pre-Clinical Meta-Analysis: Another Brick in the Wall.

Pereira A, Garzesi A, Paiva S, Polegato B Arq Bras Cardiol. 2020; 115(5):894-895.

PMID: 33295452 PMC: 8452194. DOI: 10.36660/abc.20200551.

References

Perk J, De Backer G, Gohlke H, Graham I, Reiner Z, Verschuren W . European guidelines on cardiovascular disease prevention in clinical practice (version 2012) : the fifth joint task force of the European society of cardiology and other societies on cardiovascular disease prevention in clinical practice.... Int J Behav Med. 2012; 19(4):403-88. DOI: 10.1007/s12529-012-9242-5. View

Hahn V, Lenihan D, Ky B . Cancer therapy-induced cardiotoxicity: basic mechanisms and potential cardioprotective therapies. J Am Heart Assoc. 2014; 3(2):e000665. PMC: 4187516. DOI: 10.1161/JAHA.113.000665. View

Marques-Aleixo I, Santos-Alves E, Mariani D, Rizo-Roca D, Padrao A, Rocha-Rodrigues S . Physical exercise prior and during treatment reduces sub-chronic doxorubicin-induced mitochondrial toxicity and oxidative stress. Mitochondrion. 2014; 20:22-33. DOI: 10.1016/j.mito.2014.10.008. View

Scott J, Khakoo A, Mackey J, Haykowsky M, Douglas P, Jones L . Modulation of anthracycline-induced cardiotoxicity by aerobic exercise in breast cancer: current evidence and underlying mechanisms. Circulation. 2011; 124(5):642-50. PMC: 3154075. DOI: 10.1161/CIRCULATIONAHA.111.021774. View

Dolinsky V, Rogan K, Sung M, Zordoky B, Haykowsky M, Young M . Both aerobic exercise and resveratrol supplementation attenuate doxorubicin-induced cardiac injury in mice. Am J Physiol Endocrinol Metab. 2013; 305(2):E243-53. PMC: 4116416. DOI: 10.1152/ajpendo.00044.2013. View

Hayward R, Lien C, Jensen B, Hydock D, Schneider C . Exercise training mitigates anthracycline-induced chronic cardiotoxicity in a juvenile rat model. Pediatr Blood Cancer. 2011; 59(1):149-54. DOI: 10.1002/pbc.23392. View

Ascensao A, Magalhaes J, Soares J, Ferreira R, Neuparth M, Marques F . Endurance training attenuates doxorubicin-induced cardiac oxidative damage in mice. Int J Cardiol. 2005; 100(3):451-60. DOI: 10.1016/j.ijcard.2004.11.004. View

Sturgeon K, Ky B, Libonati J, Schmitz K . The effects of exercise on cardiovascular outcomes before, during, and after treatment for breast cancer. Breast Cancer Res Treat. 2013; 143(2):219-26. PMC: 3963025. DOI: 10.1007/s10549-013-2808-3. View

Chicco A, Schneider C, Hayward R . Voluntary exercise protects against acute doxorubicin cardiotoxicity in the isolated perfused rat heart. Am J Physiol Regul Integr Comp Physiol. 2005; 289(2):R424-R431. DOI: 10.1152/ajpregu.00636.2004. View

10.

Ascensao A, Magalhaes J, Soares J, Ferreira R, Neuparth M, Marques F . Moderate endurance training prevents doxorubicin-induced in vivo mitochondriopathy and reduces the development of cardiac apoptosis. Am J Physiol Heart Circ Physiol. 2005; 289(2):H722-31. DOI: 10.1152/ajpheart.01249.2004. View

11.

Liberati A, Altman D, Tetzlaff J, Mulrow C, Gotzsche P, Ioannidis J . The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ. 2009; 339:b2700. PMC: 2714672. DOI: 10.1136/bmj.b2700. View

12.

Gewirtz D . A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. Biochem Pharmacol. 1999; 57(7):727-41. DOI: 10.1016/s0006-2952(98)00307-4. View

13.

Herrmann J, Lerman A, Sandhu N, Villarraga H, Mulvagh S, Kohli M . Evaluation and management of patients with heart disease and cancer: cardio-oncology. Mayo Clin Proc. 2014; 89(9):1287-306. PMC: 4258909. DOI: 10.1016/j.mayocp.2014.05.013. View

14.

Kouzi S, Uddin M . Aerobic Exercise Training as a Potential Cardioprotective Strategy to Attenuate Doxorubicin-Induced Cardiotoxicity. J Pharm Pharm Sci. 2016; 19(3):399-410. DOI: 10.18433/J3JS5R. View

15.

Cruz M, Duarte-Rodrigues J, Campelo M . Cardiotoxicity in anthracycline therapy: Prevention strategies. Rev Port Cardiol. 2016; 35(6):359-71. DOI: 10.1016/j.repc.2015.12.004. View

16.

Cesaretti M, Ginoza M, Ribeiro A, Kohlmann Jr O . [Systemic hemodynamic and left ventricular function of diabetic-induced hypertensive rats]. Arq Bras Endocrinol Metabol. 2011; 54(9):842-51. DOI: 10.1590/s0004-27302010000900011. View

17.

Shirinbayan V, Dabidi Roshan V . Pretreatment effect of running exercise on HSP70 and DOX-induced cardiotoxicity. Asian Pac J Cancer Prev. 2013; 13(11):5849-55. DOI: 10.7314/apjcp.2012.13.11.5849. View

18.

Adamsen L, Quist M, Andersen C, Moller T, Herrstedt J, Kronborg D . Effect of a multimodal high intensity exercise intervention in cancer patients undergoing chemotherapy: randomised controlled trial. BMJ. 2009; 339:b3410. PMC: 2762035. DOI: 10.1136/bmj.b3410. View

19.

Calve A, Haddad R, Barama S, Meilleur M, Sebag I, Chalifour L . Cardiac response to doxorubicin and dexrazoxane in intact and ovariectomized young female rats at rest and after swim training. Am J Physiol Heart Circ Physiol. 2012; 302(10):H2048-57. DOI: 10.1152/ajpheart.01069.2011. View

20.

Campos Filho O, Zielinsky P, Ortiz J, Maciel B, Andrade J, Mathias Jr W . [Guideline for indication and utilization of echocardiography in clinical practice]. Arq Bras Cardiol. 2004; 82 Suppl 2:11-34. View