Effects of Tacrolimus and Other Immune Targeting Compounds on Binge-Like Ethanol Drinking in High Drinking in the Dark Mice

Overview

Journal Neurosci Insights

Publisher Sage Publications

Specialty Neurology

Date 2020 Dec 9

PMID 33294845

Citations 3

Authors

Kolter B Grigsby

Antonia M Savarese

Pamela Metten

Barbara J Mason

Yuri A Blednov

John C Crabbe

Angela R Ozburn

Affiliations

Soon will be listed here.

Abstract

High Drinking in the Dark (HDID-1) mice represent a unique genetic risk model of binge-like drinking and a novel means of screening potential pharmacotherapies to treat alcohol use disorders (AUDs). We tested the effects of tacrolimus (0, 0.5, 1, and 2 mg/kg), sirolimus (0, 5, 10, and 20 mg/kg), palmitoylethanolamide (PEA; 0, 75, 150, and 225 mg/kg), and secukinumab (0, 5, 20, and 60 mg/kg) on binge-like ethanol intake (2-day, "Drinking in the Dark" [DID]) and blood alcohol levels (BALs) in HDID-1 mice. Tacrolimus reduced ethanol intake and BALs. Tacrolimus had no effect on water intake, but reduced saccharin intake. There was no effect of sirolimus, PEA, or secukinumab on ethanol intake or BALs. These results compare and contrast with previous work addressing these compounds or their targeted mechanisms of action on ethanol drinking, highlighting the importance of screening a wide range of models and genotypes to inform the role of neuroimmune signaling in AUDs.

Citing Articles

Sex-dependent factors of alcohol and neuroimmune mechanisms.

Cruz B, Borgonetti V, Bajo M, Roberto M Neurobiol Stress. 2023; 26:100562.

PMID: 37601537 PMC: 10432974. DOI: 10.1016/j.ynstr.2023.100562.

Midazolam, methamphetamine, morphine and nicotine intake in high-drinking-in-the-dark mice.

Savarese A, Metten P, Phillips T, Jensen B, Crabbe J, Ozburn A Addict Biol. 2022; 27(5):e13212.

PMID: 36001437 PMC: 9677807. DOI: 10.1111/adb.13212.

Corticosterone Levels and Glucocorticoid Receptor Gene Expression in High Drinking in the Dark Mice and Their Heterogeneous Stock (HS/NPT) Founder Line.

Savarese A, Grigsby K, Jensen B, Borrego M, Finn D, Crabbe J Front Behav Neurosci. 2022; 16:821859.

PMID: 35645743 PMC: 9135139. DOI: 10.3389/fnbeh.2022.821859.

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