Alterations in the Properties of Red Blood Cells in Men with Coronary Artery Diseases After Comprehensive Cardiac Rehabilitation

Overview

Journal Cardiol Res Pract

Publisher Wiley

Specialty Cardiology & Vascular Diseases

Date 2020 Dec 9

PMID 33294220

Citations 2

Authors

Krzysztof Gwozdzinski

Anna Pieniazek

Joanna Bernasinska-Slomczewska

Joanna Brzeszczynska

Robert Irzmanski

Anna Jegier

Affiliations

Soon will be listed here.

Abstract

Purpose: Comprehensive cardiac rehabilitation (CCR) is a complex program aimed at improving the health status of patients with coronary artery disease (CAD), especially those who have been subjected to cardiac interventions (PCI and CABG).The aim of this study was to measure the changes in the properties of red blood cells (RBCs) in men with CAD after cardiac intervention and after participation in CCR program.

Methods: In this study, we have investigated the influence of the physical training-based CCR program in 12 men with CAD, after PCI or CABG. The characteristics of RBCs including the basic morphology of RBCs, the conformational state of RBC membrane protein and hemoglobin, acetylcholinesterase activity, membrane fluidity, the osmotic fragility, and thiol concentration in membrane and in hemolysate were measured. Ascorbate concentration and reduced glutathione were also determined. The analysis was performed in men, before and after participation in CCR. The properties of RBCs were observed in connection with the exercise test, and parameters were evaluated before, immediately after, and 1 hour after the exercise test.

Results: After CCR, a decrease in the mobility of erythrocyte membrane proteins was observed, which was accompanied by a decrease in lipid fluidity. In addition, immediately after the exercise test and 1 hour later, we measured a decrease in thiol level in hemolysate, but not in the plasma membrane. Unexpectedly, an increase in reduced glutathione concentration one hour after the exercise test after completing comprehensive cardiac rehabilitation was observed.

Conclusion: CCR in men with CAD after cardiac intervention is connected with decreased membrane fluidity and decreased membrane protein mobility, which indicates that reduction of oxidative changes in these components occurs.

Citing Articles

Influence of Coronary Artery Bypass Grafts on Blood Aminothiols in Patients with Coronary Artery Disease.

Ivanov A, Popov M, Metelkin A, Vasilevich Aleksandrin V, Agafonov E, Kruglova M Metabolites. 2023; 13(6).

PMID: 37367901 PMC: 10305081. DOI: 10.3390/metabo13060743.

General Rehabilitation Program after Knee or Hip Replacement Significantly Influences Erythrocytes Oxidative Stress Markers and Serum ST2 Levels.

Idzik M, Poloczek J, Skrzep-Poloczek B, Chelmecka E, Jochem J, Stygar D Oxid Med Cell Longev. 2022; 2022:1358858.

PMID: 35401921 PMC: 8986427. DOI: 10.1155/2022/1358858.

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