Metabolite Profiling of Osteoporosis and Atherosclerosis in Postmenopausal Women: A Cross-Sectional Study

Overview

Journal Vasc Health Risk Manag

Publisher Dove Medical Press

Specialty Cardiology & Vascular Diseases

Date 2020 Dec 9

PMID 33293818

Citations 4

Authors

Miika Varri

Leo Niskanen

Tomi-Pekka Tuomainen

Risto Honkanen

Heikki Kroger

Marjo T Tuppurainen

Affiliations

Soon will be listed here.

Abstract

Purpose: Atherosclerosis (AS) and osteoporosis (OP) are common causes of morbidity and mortality in postmenopausal women and are connected via an unknown mechanistic link. Metabolite profiling of blood samples may allow the identification of new biomarkers and pathways for this enigmatic association.

Patients And Methods: We studied the difference in 148 metabolite levels from serum samples in postmenopausal women with AS and OP compared with those in healthy participants in this cross-sectional study. Quantitative AS was assessed by carotid artery intima-media thickness (cIMT) and carotid artery calcifications (CACs) by ultrasound, as well as OP by femoral neck (FN) bone mineral density (BMD) and 148 metabolic measures with high-throughput proton (H) nuclear magnetic resonance (NMR) in serum samples from 280 postmenopausal (PM) women. Subjects were a randomly selected subsample from the population-based Kuopio Osteoporosis Risk Factor and Prevention (OSTPRE) study. The final study population included the following groups: OP with CAC (n=16, group I), non-OP with no CAC (n=59, group II), high cIMT tertile with OP (n=11, group III) and low cIMT tertile without OP (n=48, group IV).

Results: There were differences in several metabolite levels between groups I and II. The acetate level was lower in group I compared to that in group II (group I mean ± SD: 0.033 ± 0.0070; group II: 0.041 ± 0.014, CI95%: 0.018‒0.15, p=0.014). The result was similar with diacylglycerol (p=0.002), leucine (p=0.031), valine (p=0.022) and several very low-density lipoprotein (VLDL) metabolite levels, which were lower in group I compared to those in group II. However, no associations were found in adjusted analyses with total body (TB) fat mass (FM), age and statin use (p>0.05).

Conclusion: Our novel study found differences in the metabolite profiling of altered amino acid and lipoprotein metabolism in participants with OP and AS compared with those in healthy women. The causative mechanisms remain unknown and further studies are needed.

Citing Articles

From Genomics to Metabolomics: Molecular Insights into Osteoporosis for Enhanced Diagnostic and Therapeutic Approaches.

Li Q, Wang J, Zhao C Biomedicines. 2024; 12(10).

PMID: 39457701 PMC: 11505085. DOI: 10.3390/biomedicines12102389.

Application of metabolomics in osteoporosis research.

Zhao Z, Cai Z, Chen A, Cai M, Yang K Front Endocrinol (Lausanne). 2022; 13:993253.

PMID: 36452325 PMC: 9702081. DOI: 10.3389/fendo.2022.993253.

Systematic Review of NMR-Based Metabolomics Practices in Human Disease Research.

Huang K, Thomas N, Gooley P, Armstrong C Metabolites. 2022; 12(10).

PMID: 36295865 PMC: 9609461. DOI: 10.3390/metabo12100963.

The role of metabolites under the influence of genes and lifestyles in bone density changes.

Lv X, Jiang Y, Yang D, Zhu C, Yuan H, Yuan Z Front Nutr. 2022; 9:934951.

PMID: 36118775 PMC: 9481263. DOI: 10.3389/fnut.2022.934951.

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