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A Practical Guide to Optical Coherence Tomography Angiography Interpretation

Overview
Publisher Biomed Central
Date 2020 Dec 9
PMID 33292740
Citations 25
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Abstract

Background: Optical coherence tomography angiography (OCTA) can image the retinal vasculature in vivo, without the need for contrast dye. This technology has been commercially available since 2014, however, much of its use has been limited to the research setting. Over time, more clinical practices have adopted OCTA imaging. While countless publications detail OCTA's use for the study of retinal microvasculature, few studies outline OCTA's clinical utility. BODY: This review provides an overview of OCTA imaging and details tips for successful interpretation. The review begins with a summary of OCTA technology and artifacts that arise from image acquisition. New methods and best practices to prevent image artifacts are discussed. OCTA has the unique ability among retinovascular imaging modalities to individually visualize each retinal plexus. Slabs offered in standard OCTA devices are reviewed, and clinical uses for each slab are outlined. Lastly, the use of OCTA for the clinical interpretation of retinal pathology, such as diabetic retinopathy and age-related macular degeneration, is discussed.

Conclusion: OCTA is evolving from a scientific tool to a clinical imaging device. This review provides a toolkit for successful image interpretation in a clinical setting.

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References
1.
. Fluorescein angiographic risk factors for progression of diabetic retinopathy. ETDRS report number 13. Early Treatment Diabetic Retinopathy Study Research Group. Ophthalmology. 1991; 98(5 Suppl):834-40. View

2.
Kashani A, Chen C, Gahm J, Zheng F, Richter G, Rosenfeld P . Optical coherence tomography angiography: A comprehensive review of current methods and clinical applications. Prog Retin Eye Res. 2017; 60:66-100. PMC: 5600872. DOI: 10.1016/j.preteyeres.2017.07.002. View

3.
Hwang T, Gao S, Liu L, Lauer A, Bailey S, Flaxel C . Automated Quantification of Capillary Nonperfusion Using Optical Coherence Tomography Angiography in Diabetic Retinopathy. JAMA Ophthalmol. 2016; 134(4):367-73. PMC: 4978127. DOI: 10.1001/jamaophthalmol.2015.5658. View

4.
Russell J, Shi Y, Hinkle J, Scott N, Fan K, Lyu C . Longitudinal Wide-Field Swept-Source OCT Angiography of Neovascularization in Proliferative Diabetic Retinopathy after Panretinal Photocoagulation. Ophthalmol Retina. 2019; 3(4):350-361. PMC: 6482856. DOI: 10.1016/j.oret.2018.11.008. View

5.
Arya M, Rebhun C, Alibhai A, Chen X, Moreira-Neto C, Baumal C . Parafoveal Retinal Vessel Density Assessment by Optical Coherence Tomography Angiography in Healthy Eyes. Ophthalmic Surg Lasers Imaging Retina. 2018; 49(10):S5-S17. DOI: 10.3928/23258160-20180814-02. View