Adiponectin Role in Neurodegenerative Diseases: Focus on Nutrition Review

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2020 Dec 9

PMID 33291597

Citations 13

Authors

Rita Polito

Irene Di Meo

Michelangela Barbieri

Aurora Daniele

Giuseppe Paolisso

Maria Rosaria Rizzo

Affiliations

Soon will be listed here.

Abstract

Adiponectin is an adipokine produced by adipose tissue. It has numerous beneficial effects. In particular, it improves metabolic effects and glucose homeostasis, lipid profile, and is involved in the regulation of cytokine profile and immune cell production, having anti-inflammatory and immune-regulatory effects. Adiponectin's role is already known in immune diseases and also in neurodegenerative diseases. Neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, are a set of diseases of the central nervous system, characterized by a chronic and selective process of neuron cell death, which occurs mainly in relation to oxidative stress and neuroinflammation. Lifestyle is able to influence the development of these diseases. In particular, unhealthy nutrition on gut microbiota, influences its composition and predisposition to develop many diseases such as neurodegenerative diseases, given the importance of the "gut-brain" axis. There is a strong interplay between Adiponectin, gut microbiota, and brain-gut axis. For these reasons, a healthy diet composed of healthy nutrients such as probiotics, prebiotics, polyphenols, can prevent many metabolic and inflammatory diseases such as neurodegenerative diseases and obesity. The special Adiponectin role should be taken into account also, in order to be able to use this component as a therapeutic molecule.

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References

Luna R, Foster J . Gut brain axis: diet microbiota interactions and implications for modulation of anxiety and depression. Curr Opin Biotechnol. 2014; 32:35-41. DOI: 10.1016/j.copbio.2014.10.007. View

Li Q, Lu Y, Sun L, Yan J, Yan X, Fang L . Plasma adiponectin levels in relation to prognosis in patients with angiographic coronary artery disease. Metabolism. 2012; 61(12):1803-8. DOI: 10.1016/j.metabol.2012.06.001. View

Perez-Burgos A, Wang B, Mao Y, Mistry B, McVey Neufeld K, Bienenstock J . Psychoactive bacteria Lactobacillus rhamnosus (JB-1) elicits rapid frequency facilitation in vagal afferents. Am J Physiol Gastrointest Liver Physiol. 2012; 304(2):G211-20. DOI: 10.1152/ajpgi.00128.2012. View

Vogt N, Kerby R, Dill-McFarland K, Harding S, Merluzzi A, Johnson S . Gut microbiome alterations in Alzheimer's disease. Sci Rep. 2017; 7(1):13537. PMC: 5648830. DOI: 10.1038/s41598-017-13601-y. View

Polito R, Nigro E, Pecoraro A, Monaco M, Perna F, Sanduzzi A . Adiponectin Receptors and Pro-inflammatory Cytokines Are Modulated in Common Variable Immunodeficiency Patients: Correlation With Ig Replacement Therapy. Front Immunol. 2019; 10:2812. PMC: 6890605. DOI: 10.3389/fimmu.2019.02812. View

Bravo J, Forsythe P, Chew M, Escaravage E, Savignac H, Dinan T . Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci U S A. 2011; 108(38):16050-5. PMC: 3179073. DOI: 10.1073/pnas.1102999108. View

Gareau M . Microbiota-gut-brain axis and cognitive function. Adv Exp Med Biol. 2014; 817:357-71. DOI: 10.1007/978-1-4939-0897-4_16. View

Ivanov I, de Llanos Frutos R, Manel N, Yoshinaga K, Rifkin D, Sartor R . Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe. 2008; 4(4):337-49. PMC: 2597589. DOI: 10.1016/j.chom.2008.09.009. View

Hoffman J, Tyler K, MacEachern S, Balemba O, Johnson A, Brooks E . Activation of colonic mucosal 5-HT(4) receptors accelerates propulsive motility and inhibits visceral hypersensitivity. Gastroenterology. 2012; 142(4):844-854.e4. PMC: 3477545. DOI: 10.1053/j.gastro.2011.12.041. View

10.

Gaboriau-Routhiau V, Rakotobe S, Lecuyer E, Mulder I, Lan A, Bridonneau C . The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses. Immunity. 2009; 31(4):677-89. DOI: 10.1016/j.immuni.2009.08.020. View

11.

Yamauchi T, Nio Y, Maki T, Kobayashi M, Takazawa T, Iwabu M . Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions. Nat Med. 2007; 13(3):332-9. DOI: 10.1038/nm1557. View

12.

Pusceddu M, El Aidy S, Crispie F, OSullivan O, Cotter P, Stanton C . N-3 Polyunsaturated Fatty Acids (PUFAs) Reverse the Impact of Early-Life Stress on the Gut Microbiota. PLoS One. 2015; 10(10):e0139721. PMC: 4591340. DOI: 10.1371/journal.pone.0139721. View

13.

Araujo A, Santos C, Contente H, Branco C . Air everywhere: colon perforation after colonoscopy. BMJ Case Rep. 2017; 2017. PMC: 5372200. DOI: 10.1136/bcr-2016-219178. View

14.

Sharifi-Rad M, Anil Kumar N, Zucca P, Varoni E, Dini L, Panzarini E . Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases. Front Physiol. 2020; 11:694. PMC: 7347016. DOI: 10.3389/fphys.2020.00694. View

15.

Kataoka H, Sugie K . Serum adiponectin levels between patients with Parkinson's disease and those with PSP. Neurol Sci. 2020; 41(5):1125-1131. DOI: 10.1007/s10072-019-04216-4. View

16.

Bonaz B, Sinniger V, Pellissier S . The Vagus Nerve in the Neuro-Immune Axis: Implications in the Pathology of the Gastrointestinal Tract. Front Immunol. 2017; 8:1452. PMC: 5673632. DOI: 10.3389/fimmu.2017.01452. View

17.

Braniste V, Al-Asmakh M, Kowal C, Anuar F, Abbaspour A, Toth M . The gut microbiota influences blood-brain barrier permeability in mice. Sci Transl Med. 2014; 6(263):263ra158. PMC: 4396848. DOI: 10.1126/scitranslmed.3009759. View

18.

Mazzoli A, Spagnuolo M, Gatto C, Nazzaro M, Cancelliere R, Crescenzo R . Adipose Tissue and Brain Metabolic Responses to Western Diet-Is There a Similarity between the Two?. Int J Mol Sci. 2020; 21(3). PMC: 7036881. DOI: 10.3390/ijms21030786. View

19.

Reinshagen M, von Boyen G, Adler G, Steinkamp M . Role of neurotrophins in inflammation of the gut. Curr Opin Investig Drugs. 2002; 3(4):565-8. View

20.

Wong R, Yang C, Song G, Wong J, Ho K . Melatonin regulation as a possible mechanism for probiotic (VSL#3) in irritable bowel syndrome: a randomized double-blinded placebo study. Dig Dis Sci. 2014; 60(1):186-94. DOI: 10.1007/s10620-014-3299-8. View