Associations Between Red Blood Cell and Platelet Transfusions and Retinopathy of Prematurity

Overview

Journal Neonatology

Publisher Karger

Specialty Gynecology & Obstetrics

Date 2020 Dec 8

PMID 33291117

Citations 11

Authors

Tobias Hengartner

Mark Adams

Riccardo E Pfister

Diane Snyers

Jane McDougall

Salome Waldvogel

Katrin Held-Egli

Lea Spring

Bjarte Rogdo

Thomas Riedel

Romaine Arlettaz Mieth

Affiliations

Soon will be listed here.

Abstract

Aim: The aim of this study is to examine possible associations between the transfusion of RBC or platelets (PLTs) and the development of retinopathy of prematurity (ROP) in infants.

Methods: This retrospective, national, case-control study included all live births in Switzerland between 2013 and 2018. We investigated preterm infants at a gestational age of <28 weeks, who developed higher stage ROP (≥stage 2, n = 178). Each case infant was matched to another of the same sex who did not develop ROP (n = 178, control group).

Results: When compared with the control group, we observed higher numbers of RBC transfusions per infant and higher percentages of infants receiving PLT transfusions in the case group. An adjusted logistic regression analysis revealed that both RBC (odds ratio [OR] 1.081, 95% confidence interval [CI] 1.020-1.146) and PLT transfusions (OR = 2.502, 95% CI 1.566-3.998) numbers were associated with ROP development.

Conclusions: Multiple RBC and PLT transfusions are associated with higher stage ROP development. Prospective studies are required to determine their potential as risk factors.

Citing Articles

Association between hematocrit in the first two hours of life and retinopathy during prematurity: a retrospective study from DRYAD.

Kong X, Wang H, Yang R, Zhang M, Li C, Zhang R BMC Pediatr. 2025; 25(1):176.

PMID: 40057690 PMC: 11889788. DOI: 10.1186/s12887-025-05533-8.

Red Blood Cell Transfusion for Incidence of Retinopathy of Prematurity: Prospective Multicenter Cohort Study.

Wang X, Rao R, Li H, Lei X, Dong W JMIR Pediatr Parent. 2024; 7:e60330.

PMID: 39297519 PMC: 11425406. DOI: 10.2196/60330.

Progress in the study of association between hematological indicators and retinopathy of prematurity (Review).

Tang W, Zhang Y, Zhang H, Li K, Zhao Z, Ma H Biomed Rep. 2024; 21(2):111.

PMID: 38912168 PMC: 11190637. DOI: 10.3892/br.2024.1799.

Platelet Counts and Risk of Severe Retinopathy of Prematurity: A Bayesian Model-Averaged Meta-Analysis.

Almutairi M, Gulden S, Hundscheid T, Bartos F, Cavallaro G, Villamor E Children (Basel). 2023; 10(12).

PMID: 38136105 PMC: 10741847. DOI: 10.3390/children10121903.

Effect of autologous umbilical cord blood transfusion in the development of retinopathy of prematurity: randomized clinical trial - study protocol.

Torrejon-Rodriguez L, Pinilla-Gonzalez A, Lara Canton I, Albiach-Delgado A, Cascant-Vilaplana M, Cernada M Front Pediatr. 2023; 11:1269797.

PMID: 37900679 PMC: 10602804. DOI: 10.3389/fped.2023.1269797.

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