Healing of Partial Tear of the Supraspinatus Tendon After Atelocollagen Injection Confirmed by MRI: A Case Report

Overview

Journal Medicine (Baltimore)

Specialty General Medicine

Date 2020 Dec 8

PMID 33285757

Citations 2

Authors

Youbin Jo

Won-Joong Kim

Heeseung Lee

Affiliations

Soon will be listed here.

Abstract

Rationale: Recently, collagen therapy has been made available for treating rotator cuff tendon injuries. However, to our knowledge, there are no clinical studies objectively investigating the effect of collagen therapy.

Patient Concerns: A 53-year-old female patient visited our pain clinic because of pain in the right shoulder. Although she had never experienced trauma and had not overused her shoulder and arm, the patient showed limited range of motion with painful arc syndrome. Moreover, the Neer test and Hawkins-Kennedy test were positive with subacromial tenderness.

Diagnoses: The MRI findings revealed partial tears on the articular surface of the anterior supraspinatus tendon in the rotator cuff.

Interventions: The patient was treated with injections of exogenous collagen at the site of the partial tear under ultrasound guidance.

Outcomes: Follow-up MRI after injection of collagen revealed healing of the previous partial rupture of the tendon without any complications. Moreover, the patient reported reduction in pain and improvement in the movement of her shoulder during the follow-up period.

Lessons: In this report, we demonstrate healing of a partial tear of the supraspinatus tendon in the rotator cuff after injection of exogenous collagen, as confirmed by MRI.

Citing Articles

Collagen Injections for Rotator Cuff Diseases: A Systematic Review.

Aicale R, Savarese E, Mottola R, Corrado B, Sirico F, Pellegrino R Clin Pract. 2025; 15(2).

PMID: 39996698 PMC: 11854470. DOI: 10.3390/clinpract15020028.

Rotator cuff tears.

Bedi A, Bishop J, Keener J, Lansdown D, Levy O, Macdonald P Nat Rev Dis Primers. 2024; 10(1):8.

PMID: 38332156 DOI: 10.1038/s41572-024-00492-3.

Effects of Arthroscopic Atelocollagen Insertion in High-Grade Partial Articular Supraspinatus Tendon Avulsion Lesions: A Retrospective Cohort Study With Propensity Score Matching.

Ji J, Choi C, You H, Parikh D, Oh S Orthop J Sports Med. 2023; 11(11):23259671231212882.

PMID: 38035219 PMC: 10683401. DOI: 10.1177/23259671231212882.

References

Fukuda H, Hamada K, Yamanaka K . Pathology and pathogenesis of bursal-side rotator cuff tears viewed from en bloc histologic sections. Clin Orthop Relat Res. 1990; (254):75-80. View

Joseph M, Maresh C, McCarthy M, Kraemer W, Ledgard F, Arciero C . Histological and molecular analysis of the biceps tendon long head post-tenotomy. J Orthop Res. 2009; 27(10):1379-85. DOI: 10.1002/jor.20868. View

Suh D, Lee J, Yoo J, Woo S, Kim G, Kim J . Atelocollagen Enhances the Healing of Rotator Cuff Tendon in Rabbit Model. Am J Sports Med. 2017; 45(9):2019-2027. DOI: 10.1177/0363546517703336. View

Rabago D, Patterson J, Mundt M, Kijowski R, Grettie J, Segal N . Dextrose prolotherapy for knee osteoarthritis: a randomized controlled trial. Ann Fam Med. 2013; 11(3):229-37. PMC: 3659139. DOI: 10.1370/afm.1504. View

Massoud E . Healing of subcutaneous tendons: Influence of the mechanical environment at the suture line on the healing process. World J Orthop. 2013; 4(4):229-40. PMC: 3801242. DOI: 10.5312/wjo.v4.i4.229. View

Boudreault J, Desmeules F, Roy J, Dionne C, Fremont P, MacDermid J . The efficacy of oral non-steroidal anti-inflammatory drugs for rotator cuff tendinopathy: a systematic review and meta-analysis. J Rehabil Med. 2014; 46(4):294-306. DOI: 10.2340/16501977-1800. View

Wei A, Callaci J, Juknelis D, Marra G, Tonino P, Freedman K . The effect of corticosteroid on collagen expression in injured rotator cuff tendon. J Bone Joint Surg Am. 2006; 88(6):1331-8. PMC: 3071041. DOI: 10.2106/JBJS.E.00806. View

Thankam F, Dilisio M, Agrawal D . Immunobiological factors aggravating the fatty infiltration on tendons and muscles in rotator cuff lesions. Mol Cell Biochem. 2016; 417(1-2):17-33. DOI: 10.1007/s11010-016-2710-5. View

Thon S, OMalley 2nd L, OBrien M, Savoie 3rd F . Evaluation of Healing Rates and Safety With a Bioinductive Collagen Patch for Large and Massive Rotator Cuff Tears: 2-Year Safety and Clinical Outcomes. Am J Sports Med. 2019; 47(8):1901-1908. DOI: 10.1177/0363546519850795. View

10.

Thankam F, Roesch Z, Dilisio M, Radwan M, Kovilam A, Gross R . Association of Inflammatory Responses and ECM Disorganization with HMGB1 Upregulation and NLRP3 Inflammasome Activation in the Injured Rotator Cuff Tendon. Sci Rep. 2018; 8(1):8918. PMC: 5995925. DOI: 10.1038/s41598-018-27250-2. View

11.

Thankam F, Evan D, Agrawal D, Dilisio M . Collagen type III content of the long head of the biceps tendon as an indicator of glenohumeral arthritis. Mol Cell Biochem. 2018; 454(1-2):25-31. DOI: 10.1007/s11010-018-3449-y. View

12.

Fukuda H, Hamada K, Nakajima T, Tomonaga A . Pathology and pathogenesis of the intratendinous tearing of the rotator cuff viewed from en bloc histologic sections. Clin Orthop Relat Res. 1994; (304):60-7. View

13.

Thankam F, Boosani C, Dilisio M, Dietz N, Agrawal D . MicroRNAs Associated with Shoulder Tendon Matrisome Disorganization in Glenohumeral Arthritis. PLoS One. 2016; 11(12):e0168077. PMC: 5161352. DOI: 10.1371/journal.pone.0168077. View

14.

Thankam F, Dilisio M, Dietz N, Agrawal D . TREM-1, HMGB1 and RAGE in the Shoulder Tendon: Dual Mechanisms for Inflammation Based on the Coincidence of Glenohumeral Arthritis. PLoS One. 2016; 11(10):e0165492. PMC: 5085056. DOI: 10.1371/journal.pone.0165492. View

15.

Hynes R . Integrins: bidirectional, allosteric signaling machines. Cell. 2002; 110(6):673-87. DOI: 10.1016/s0092-8674(02)00971-6. View

16.

Canty E, Kadler K . Procollagen trafficking, processing and fibrillogenesis. J Cell Sci. 2005; 118(Pt 7):1341-53. DOI: 10.1242/jcs.01731. View

17.

Thankam F, Dilisio M, Gross R, Agrawal D . Collagen I: a kingpin for rotator cuff tendon pathology. Am J Transl Res. 2019; 10(11):3291-3309. PMC: 6291732. View

18.

Hamada K, Tomonaga A, Gotoh M, Yamakawa H, Fukuda H . Intrinsic healing capacity and tearing process of torn supraspinatus tendons: in situ hybridization study of alpha 1 (I) procollagen mRNA. J Orthop Res. 1997; 15(1):24-32. DOI: 10.1002/jor.1100150105. View

19.

Fukuda H . Partial-thickness rotator cuff tears: a modern view on Codman's classic. J Shoulder Elbow Surg. 2000; 9(2):163-8. View

20.

Schneeberger A, Nyffeler R, Gerber C . Structural changes of the rotator cuff caused by experimental subacromial impingement in the rat. J Shoulder Elbow Surg. 1998; 7(4):375-80. DOI: 10.1016/s1058-2746(98)90026-x. View