Acupuncture for Opioid-induced Constipation: Protocol for a Systematic Review and Meta-analysis

Overview

Journal Medicine (Baltimore)

Specialty General Medicine

Date 2020 Dec 8

PMID 33285714

Citations 2

Authors

Pu Yang

Yuanchun Wang

Yingchun Xiao

Qiaolin Ma

Runhong Ma

Jing Mi

Jianrong Hui

Affiliations

Soon will be listed here.

Abstract

Background: Opioid-induced constipation (OIC) is one of the most common complications of analgesic therapy for cancer pain patients who suffer moderate to severe pain. Acupuncture as an effective treatment in constipation has been widely applied. But its efficacy has not been assessed systematically. Thus, the purpose of this study is to provide a protocol to explore the efficacy and safety of acupuncture for OIC.

Methods: Randomized Controlled Trials (RCTs) of acupuncture treatment for OIC in 4 Chinese electronic databases (China National Knowledge Infrastructure, Chinese Biological and Medical Database, China Scientific Journal Database, Wan-Fang Data) and 3 English electronic databases (PubMed, Embase, Cochrane Library) will be searched from their inception to September 31, 2020. RevMan 5.3 software and Stata 14.0 software will be used for meta-analysis, EndNote X9.2 and Cochrane Risk of Bias Tool will be used for literature screening and quality assessment.

Results: This study will present an assessment of the efficacy and safety of acupuncture treatment for OIC patients through summarize high-quality clinical evidence.

Conclusion: The conclusion of our systematic review and meta-analysis may provide evidence of whether acupuncture treatment is beneficial to patients with OIC.INPLASY registration number: INPLASY2020100026.

Citing Articles

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Naldemedine-induced perforation of a diverticulum in the sigmoid colon of a patient with opioid-related constipation: a case report.

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References

Larkin P, Cherny N, La Carpia D, Guglielmo M, Ostgathe C, Scotte F . Diagnosis, assessment and management of constipation in advanced cancer: ESMO Clinical Practice Guidelines. Ann Oncol. 2018; 29(Suppl 4):iv111-iv125. DOI: 10.1093/annonc/mdy148. View

Zhu X, Liu Z, Qu H, Niu W, Gao L, Wang Y . The effect and mechanism of electroacupuncture at LI11 and ST37 on constipation in a rat model. Acupunct Med. 2015; 34(3):194-200. PMC: 4941155. DOI: 10.1136/acupmed-2015-010897. View

Cai H, Zhou Q, Bao G, Kong X, Gong L . Transcutaneous electrical nerve stimulation of acupuncture points enhances therapeutic effects of oral lactulose solution on opioid-induced constipation. J Int Med Res. 2019; 47(12):6337-6348. PMC: 7045659. DOI: 10.1177/0300060519874539. View

Crockett S, Greer K, Sultan S . Opioid-Induced Constipation (OIC) Guideline. Gastroenterology. 2018; 156(1):228. DOI: 10.1053/j.gastro.2018.10.044. View

Gaertner J, Siemens W, Camilleri M, Davies A, Drossman D, Webster L . Definitions and outcome measures of clinical trials regarding opioid-induced constipation: a systematic review. J Clin Gastroenterol. 2014; 49(1):9-16. DOI: 10.1097/MCG.0000000000000246. View

Zhang F, Lin H, He Q . [Effect of electro-acupuncture in treating morphine sulfate caused constipation in tumor patients]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2010; 29(10):922-5. View

Wang X, Yang B, Yin J, Wei W, Chen J . Electroacupuncture via chronically implanted electrodes improves gastrointestinal motility by balancing sympathovagal activities in a rat model of constipation. Am J Physiol Gastrointest Liver Physiol. 2019; 316(6):G797-G805. DOI: 10.1152/ajpgi.00018.2018. View

Sera L, McPherson M . Management of Opioid-Induced Constipation in Hospice Patients. Am J Hosp Palliat Care. 2017; 35(2):330-335. DOI: 10.1177/1049909117705379. View

Lu W, Rosenthal D . Acupuncture for cancer pain and related symptoms. Curr Pain Headache Rep. 2013; 17(3):321. PMC: 4008096. DOI: 10.1007/s11916-013-0321-3. View

10.

Wiffen P, Derry S, Moore R, McNicol E, Bell R, Carr D . Oral paracetamol (acetaminophen) for cancer pain. Cochrane Database Syst Rev. 2017; 7:CD012637. PMC: 6369932. DOI: 10.1002/14651858.CD012637.pub2. View

11.

Webster L . Opioid-Induced Constipation. Pain Med. 2015; 16 Suppl 1:S16-21. DOI: 10.1111/pme.12911. View

12.

Bandieri E, Romero M, Ripamonti C, Artioli F, Sichetti D, Fanizza C . Randomized Trial of Low-Dose Morphine Versus Weak Opioids in Moderate Cancer Pain. J Clin Oncol. 2015; 34(5):436-42. DOI: 10.1200/JCO.2015.61.0733. View

13.

Muller-Lissner S, Bassotti G, Coffin B, Drewes A, Breivik H, Eisenberg E . Opioid-Induced Constipation and Bowel Dysfunction: A Clinical Guideline. Pain Med. 2016; 18(10):1837-1863. PMC: 5914368. DOI: 10.1093/pm/pnw255. View

14.

Hutson J, Dughetti L, Stathopoulos L, Southwell B . Transabdominal electrical stimulation (TES) for the treatment of slow-transit constipation (STC). Pediatr Surg Int. 2015; 31(5):445-51. DOI: 10.1007/s00383-015-3681-4. View

15.

Farmer A, Holt C, Downes T, Ruggeri E, Del Vecchio S, De Giorgio R . Pathophysiology, diagnosis, and management of opioid-induced constipation. Lancet Gastroenterol Hepatol. 2018; 3(3):203-212. DOI: 10.1016/S2468-1253(18)30008-6. View

16.

Mesia R, Virizuela Echaburu J, Gomez J, Sauri T, Serrano G, Pujol E . Opioid-Induced Constipation in Oncological Patients: New Strategies of Management. Curr Treat Options Oncol. 2019; 20(12):91. PMC: 6920224. DOI: 10.1007/s11864-019-0686-6. View

17.

Farmer A, Drewes A, Chiarioni G, De Giorgio R, OBrien T, Morlion B . Pathophysiology and management of opioid-induced constipation: European expert consensus statement. United European Gastroenterol J. 2019; 7(1):7-20. PMC: 6374852. DOI: 10.1177/2050640618818305. View

18.

Crockett S, Greer K, Heidelbaugh J, Falck-Ytter Y, Hanson B, Sultan S . American Gastroenterological Association Institute Guideline on the Medical Management of Opioid-Induced Constipation. Gastroenterology. 2018; 156(1):218-226. DOI: 10.1053/j.gastro.2018.07.016. View

19.

Zhu H, Gong Z, Hu B, Wei Q, Kong J, Peng C . The Efficacy and Safety of Transcutaneous Acupoint Interferential Current Stimulation for Cancer Pain Patients With Opioid-Induced Constipation: A Prospective Randomized Controlled Study. Integr Cancer Ther. 2017; 17(2):437-443. PMC: 6041914. DOI: 10.1177/1534735417734910. View

20.

Rao V, Micic D, Davis A . Medical Management of Opioid-Induced Constipation. JAMA. 2019; 322(22):2241-2242. DOI: 10.1001/jama.2019.15852. View