Effects of Electronic Nicotine Delivery Systems and Cigarettes on Systemic Circulation and Blood-Brain Barrier: Implications for Cognitive Decline

Overview

Journal Am J Pathol

Publisher Elsevier

Specialty Pathology

Date 2020 Dec 7

PMID 33285126

Citations 9

Authors

Nathan A Heldt

Nancy Reichenbach

Hannah M McGary

Yuri Persidsky

Affiliations

Soon will be listed here.

Abstract

Electronic nicotine delivery systems (often known as e-cigarettes) are a novel tobacco product with growing popularity, particularly among younger demographics. The implications for public health are twofold, as these products may represent a novel source of tobacco-associated disease but may also provide a harm reduction strategy for current tobacco users. There is increasing recognition that e-cigarettes impact vascular function across multiple organ systems. Herein, we provide a comparison of evidence regarding the role of e-cigarettes versus combustible tobacco in vascular disease and implications for blood-brain barrier dysfunction and cognitive decline. Multiple non-nicotinic components of tobacco smoke have been identified in e-cigarette aerosol, and their involvement in vascular disease is discussed. In addition, nicotine and nicotinic signaling may modulate peripheral immune and endothelial cell populations in a highly context-dependent manner. Direct preclinical evidence for electronic nicotine delivery system-associated neurovascular impairment is provided, and a model is proposed in which non-nicotinic elements exert a proinflammatory effect that is functionally antagonized by the presence of nicotine.

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References

Chatterjee S, Tao J, Johncola A, Guo W, Caporale A, Langham M . Acute exposure to e-cigarettes causes inflammation and pulmonary endothelial oxidative stress in nonsmoking, healthy young subjects. Am J Physiol Lung Cell Mol Physiol. 2019; 317(2):L155-L166. PMC: 6734380. DOI: 10.1152/ajplung.00110.2019. View

van der Zanden E, Hilbers F, Verseijden C, van den Wijngaard R, Skynner M, Lee K . Nicotinic acetylcholine receptor expression and susceptibility to cholinergic immunomodulation in human monocytes of smoking individuals. Neuroimmunomodulation. 2012; 19(4):255-65. PMC: 7068785. DOI: 10.1159/000335185. View

Gray J, Thompson M, Bachman C, Owens M, Murphy M, Palmer R . Associations of cigarette smoking with gray and white matter in the UK Biobank. Neuropsychopharmacology. 2020; 45(7):1215-1222. PMC: 7235023. DOI: 10.1038/s41386-020-0630-2. View

Heiss C, Amabile N, Lee A, Real W, Schick S, Lao D . Brief secondhand smoke exposure depresses endothelial progenitor cells activity and endothelial function: sustained vascular injury and blunted nitric oxide production. J Am Coll Cardiol. 2008; 51(18):1760-71. DOI: 10.1016/j.jacc.2008.01.040. View

Csordas A, Bernhard D . The biology behind the atherothrombotic effects of cigarette smoke. Nat Rev Cardiol. 2013; 10(4):219-30. DOI: 10.1038/nrcardio.2013.8. View

Shaffer R, Sheppard L, Peskind E, Zhang J, Adar S, Li G . Fine Particulate Matter Exposure and Cerebrospinal Fluid Markers of Vascular Injury. J Alzheimers Dis. 2019; 71(3):1015-1025. PMC: 7147945. DOI: 10.3233/JAD-190563. View

Jellinger K, Attems J . Prevalence of dementia disorders in the oldest-old: an autopsy study. Acta Neuropathol. 2010; 119(4):421-33. DOI: 10.1007/s00401-010-0654-5. View

Wayne G, Connolly G, Henningfield J . Brand differences of free-base nicotine delivery in cigarette smoke: the view of the tobacco industry documents. Tob Control. 2006; 15(3):189-98. PMC: 2564657. DOI: 10.1136/tc.2005.013805. View

Kaisar M, Villalba H, Prasad S, Liles T, Sifat A, Sajja R . Offsetting the impact of smoking and e-cigarette vaping on the cerebrovascular system and stroke injury: Is Metformin a viable countermeasure?. Redox Biol. 2017; 13:353-362. PMC: 5480985. DOI: 10.1016/j.redox.2017.06.006. View

10.

Carnevale R, Sciarretta S, Violi F, Nocella C, Loffredo L, Perri L . Acute Impact of Tobacco vs Electronic Cigarette Smoking on Oxidative Stress and Vascular Function. Chest. 2016; 150(3):606-12. DOI: 10.1016/j.chest.2016.04.012. View

11.

Goniewicz M, Smith D, Edwards K, Blount B, Caldwell K, Feng J . Comparison of Nicotine and Toxicant Exposure in Users of Electronic Cigarettes and Combustible Cigarettes. JAMA Netw Open. 2019; 1(8):e185937. PMC: 6324349. DOI: 10.1001/jamanetworkopen.2018.5937. View

12.

Bitzer Z, Goel R, Reilly S, Bhangu G, Trushin N, Foulds J . Emissions of Free Radicals, Carbonyls, and Nicotine from the NIDA Standardized Research Electronic Cigarette and Comparison to Similar Commercial Devices. Chem Res Toxicol. 2018; 32(1):130-138. PMC: 8323638. DOI: 10.1021/acs.chemrestox.8b00235. View

13.

Abbott N, Patabendige A, Dolman D, Yusof S, Begley D . Structure and function of the blood-brain barrier. Neurobiol Dis. 2009; 37(1):13-25. DOI: 10.1016/j.nbd.2009.07.030. View

14.

White J, Li J, Newcombe R, Walton D . Tripling use of electronic cigarettes among New Zealand adolescents between 2012 and 2014. J Adolesc Health. 2015; 56(5):522-8. DOI: 10.1016/j.jadohealth.2015.01.022. View

15.

Allen J, Flanigan S, LeBlanc M, Vallarino J, MacNaughton P, Stewart J . Flavoring Chemicals in E-Cigarettes: Diacetyl, 2,3-Pentanedione, and Acetoin in a Sample of 51 Products, Including Fruit-, Candy-, and Cocktail-Flavored E-Cigarettes. Environ Health Perspect. 2015; 124(6):733-9. PMC: 4892929. DOI: 10.1289/ehp.1510185. View

16.

Chavan S, Tracey K . Essential Neuroscience in Immunology. J Immunol. 2017; 198(9):3389-3397. PMC: 5426063. DOI: 10.4049/jimmunol.1601613. View

17.

Hebert L, Scherr P, Beckett L, Funkenstein H, Albert M, Chown M . Relation of smoking and alcohol consumption to incident Alzheimer's disease. Am J Epidemiol. 1992; 135(4):347-55. DOI: 10.1093/oxfordjournals.aje.a116296. View

18.

Tang M, Wu X, Lee H, Xia Y, Deng F, Moreira A . Electronic-cigarette smoke induces lung adenocarcinoma and bladder urothelial hyperplasia in mice. Proc Natl Acad Sci U S A. 2019; 116(43):21727-21731. PMC: 6815158. DOI: 10.1073/pnas.1911321116. View

19.

Chatterjee P, Al-Abed Y, Sherry B, Metz C . Cholinergic agonists regulate JAK2/STAT3 signaling to suppress endothelial cell activation. Am J Physiol Cell Physiol. 2009; 297(5):C1294-306. PMC: 2777398. DOI: 10.1152/ajpcell.00160.2009. View

20.

de Lacy E, Fletcher A, Hewitt G, Murphy S, Moore G . Cross-sectional study examining the prevalence, correlates and sequencing of electronic cigarette and tobacco use among 11-16-year olds in schools in Wales. BMJ Open. 2017; 7(2):e012784. PMC: 5294000. DOI: 10.1136/bmjopen-2016-012784. View