Overview of Plasma and Platelet Transfusions in Critically Ill Children

Overview

Journal Front Pediatr

Specialty Pediatrics

Date 2020 Dec 7

PMID 33282804

Citations 3

Authors

Stacie Kahn

Madhuradhar Chegondi

Marianne E Nellis

Oliver Karam

Affiliations

Soon will be listed here.

Abstract

Critically ill children are a unique population who frequently receive plasma and platelet transfusions for both active bleeding and mitigation of bleeding risk. While these products are frequently administered, transfusion indications in this population remain unclear, and practice varies across institutions and providers. In this manuscript, we will outline the current evidence regarding plasma and platelet transfusions for hemostasis in the pediatric intensive care setting. For both products, we will describe the product composition, epidemiology, and product indications and discuss the potential risks and benefits involved with the transfusion. We will also discuss knowledge gaps and future areas of research.

Citing Articles

Effect of Platelet Transfusions on Extracorporeal Life Support Oxygenator's Function.

Chegondi M, Vijayakumar N, Badheka A, Karam O Front Pediatr. 2022; 10:826477.

PMID: 35321010 PMC: 8936087. DOI: 10.3389/fped.2022.826477.

What Laboratory Tests and Physiologic Triggers Should Guide the Decision to Administer a Platelet or Plasma Transfusion in Critically Ill Children and What Product Attributes Are Optimal to Guide Specific Product Selection? From the Transfusion and....

Delaney M, Karam O, Lieberman L, Steffen K, Muszynski J, Goel R Pediatr Crit Care Med. 2022; 23(13 Suppl 1 1S):e1-e13.

PMID: 34989701 PMC: 8769352. DOI: 10.1097/PCC.0000000000002854.

Neonatal platelet physiology and implications for transfusion.

Ferrer-Marin F, Sola-Visner M Platelets. 2021; 33(1):14-22.

PMID: 34392772 PMC: 8795471. DOI: 10.1080/09537104.2021.1962837.

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