Tellurium Doped Zinc Imidazole Framework (Te@ZIF-8) for Quantitative Determination of Hydrogen Peroxide from Serum of Pancreatic Cancer Patients

Overview

Journal Sci Rep

Specialty Science

Date 2020 Dec 4

PMID 33273679

Citations 2

Authors

Batool Fatima

Dilshad Hussain

Adeela Saeed

Muhammad Salman Sajid

Saadat Majeed

Rahat Nawaz

Muhammad Naeem Ashiq

Muhammad Najam-Ul-Haq

Rubaida Mehmood

Affiliations

Soon will be listed here.

Abstract

The tellurium doped zinc imidazole framework (Te@ZIF-8) is prepared by a two-step hydrothermal strategy for the electrochemical sensing of hydrogen peroxide. Material is characterized by transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC). The electrochemical characterization of the MOF modified electrode is done by a three-electrode system. Electrochemical sensing of hydrogen peroxide is made by cyclic voltammetry, amperometry, and impedance measurements. Results demonstrate that Te@ZIF-8 shows a detection limit of 60 µM with linearity up to 0.98855. Material is stable to 1000 cycles with no significant change in electrochemical response. Amperometry depicts the recovery of hydrogen peroxide from human serum up to 101%. Impedance curve reveals the surface of Te@ZIF-8-GCE (glassy carbon electrode) as porous and rough and an interface is developed between analyte ions and the sensing material. Finally, the modified electrode is used for the quantitative determination of hydrogen peroxide from serum samples of pancreatic cancer patients, diagnosed with CA 19-9.

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