Early Diagnosis of COPD: Myth or a True Perspective

Overview

Journal Eur Respir Rev

Specialty Pulmonary Medicine

Date 2020 Dec 3

PMID 33268437

Citations 13

Authors

Maria Eugenia Laucho-Contreras

Mark Cohen-Todd

Affiliations

Soon will be listed here.

Abstract

The early stages of COPD have recently become a hot topic as many new risk factors have been proposed, but substantial knowledge gaps remain in explaining the natural history of the disease. If we are to modify the outcomes of COPD, early detection needs to play a critical role. However, we need to sort out the barriers to early detection and have a better understanding of the definition of COPD and its diagnosis and therapeutic strategies to identify and treat patients with COPD before structural changes progress. In this review, we aim to clarify the differences between early COPD, mild COPD and early detection of COPD, with an emphasis on the clinical burden and how different outcomes (quality of life, exacerbation, cost and mortality) are modified depending on which definition is used. We will summarise the evidence for the new multidimensional diagnostic approaches to detecting early pathophysiologic changes that potentially allow for future studies on COPD management strategies to halt or prevent disease development.

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References

Martinez F, Han M, Allinson J, Barr R, Boucher R, Calverley P . At the Root: Defining and Halting Progression of Early Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2018; 197(12):1540-1551. PMC: 6006401. DOI: 10.1164/rccm.201710-2028PP. View

Marsh S, Aldington S, Williams M, Weatherall M, Shirtcliffe P, McNaughton A . Complete reference ranges for pulmonary function tests from a single New Zealand population. N Z Med J. 2006; 119(1244):U2281. View

Laucho-Contreras M, Montes de Oca M, Owen C . Asthma COPD Overlap Syndrome: An Approach to A Real -World Endotype in Obstructive Lung Disease?. Curr Pharm Des. 2016; 22(41):6273-6282. DOI: 10.2174/1381612822666160906162441. View

Leidy N, Martinez F, Malley K, Mannino D, Han M, Bacci E . Can CAPTURE be used to identify undiagnosed patients with mild-to-moderate COPD likely to benefit from treatment?. Int J Chron Obstruct Pulmon Dis. 2018; 13:1901-1912. PMC: 6005334. DOI: 10.2147/COPD.S152226. View

Larsson K, Janson C, Stallberg B, Lisspers K, Olsson P, Kostikas K . Impact of COPD diagnosis timing on clinical and economic outcomes: the ARCTIC observational cohort study. Int J Chron Obstruct Pulmon Dis. 2019; 14:995-1008. PMC: 6526023. DOI: 10.2147/COPD.S195382. View

Vestbo J, Lange P . Can GOLD Stage 0 provide information of prognostic value in chronic obstructive pulmonary disease?. Am J Respir Crit Care Med. 2002; 166(3):329-32. DOI: 10.1164/rccm.2112048. View

Foreman M, Zhang L, Murphy J, Hansel N, Make B, Hokanson J . Early-onset chronic obstructive pulmonary disease is associated with female sex, maternal factors, and African American race in the COPDGene Study. Am J Respir Crit Care Med. 2011; 184(4):414-20. PMC: 3175544. DOI: 10.1164/rccm.201011-1928OC. View

Gingo M, Nouraie M, Kessinger C, Greenblatt R, Huang L, Kleerup E . Decreased Lung Function and All-Cause Mortality in HIV-infected Individuals. Ann Am Thorac Soc. 2018; 15(2):192-199. PMC: 5822404. DOI: 10.1513/AnnalsATS.201606-492OC. View

Labonte L, Tan W, Li P, Mancino P, Aaron S, Benedetti A . Undiagnosed Chronic Obstructive Pulmonary Disease Contributes to the Burden of Health Care Use. Data from the CanCOLD Study. Am J Respir Crit Care Med. 2016; 194(3):285-98. DOI: 10.1164/rccm.201509-1795OC. View

10.

Pauwels R, Buist A, Calverley P, Jenkins C, Hurd S . Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary. Am J Respir Crit Care Med. 2001; 163(5):1256-76. DOI: 10.1164/ajrccm.163.5.2101039. View

11.

Montes de Oca M, Lopez Varela M, Acuna A, Schiavi E, Casas A, Tokumoto A . Incorporating New Evidence on Inhaled Medications in COPD. The Latin American Chest Association (ALAT) 2019. Arch Bronconeumol (Engl Ed). 2019; 56(2):106-113. DOI: 10.1016/j.arbres.2019.09.023. View

12.

De Ramon Fernandez A, Ruiz Fernandez D, Marcos-Jorquera D, Gilart Iglesias V . Support System for Early Diagnosis of Chronic Obstructive Pulmonary Disease Based on the Service-Oriented Architecture Paradigm and Business Process Management Strategy: Development and Usability Survey Among Patients and Health Care Providers. J Med Internet Res. 2020; 22(3):e17161. PMC: 7109614. DOI: 10.2196/17161. View

13.

Mohamed Hoesein F, de Jong P, Lammers J, Mali W, Schmidt M, de Koning H . Airway wall thickness associated with forced expiratory volume in 1 second decline and development of airflow limitation. Eur Respir J. 2015; 45(3):644-51. DOI: 10.1183/09031936.00020714. View

14.

Vestbo J, Edwards L, Scanlon P, Yates J, Agusti A, Bakke P . Changes in forced expiratory volume in 1 second over time in COPD. N Engl J Med. 2011; 365(13):1184-92. DOI: 10.1056/NEJMoa1105482. View

15.

Di Marco F, Balbo P, Blasio F, Cardaci V, Crimi N, Girbino G . Early management of COPD: where are we now and where do we go from here? A Delphi consensus project. Int J Chron Obstruct Pulmon Dis. 2019; 14:353-360. PMC: 6366359. DOI: 10.2147/COPD.S176662. View

16.

Yakar H, Gunen H, Pehlivan E, Aydogan S . The role of tuberculosis in COPD. Int J Chron Obstruct Pulmon Dis. 2017; 12:323-329. PMC: 5261555. DOI: 10.2147/COPD.S116086. View

17.

Petersen H, Sood A, Polverino F, Owen C, Pinto-Plata V, Celli B . The Course of Lung Function in Middle-aged Heavy Smokers: Incidence and Time to Early Onset of Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2018; 198(11):1449-1451. PMC: 6290951. DOI: 10.1164/rccm.201805-0861LE. View

18.

Price D, Tinkelman D, Halbert R, Nordyke R, Isonaka S, Nonikov D . Symptom-based questionnaire for identifying COPD in smokers. Respiration. 2005; 73(3):285-95. DOI: 10.1159/000090142. View

19.

Arjomandi M, Zeng S, Barjaktarevic I, Barr R, Bleecker E, Bowler R . Radiographic lung volumes predict progression to COPD in smokers with preserved spirometry in SPIROMICS. Eur Respir J. 2019; 54(4). PMC: 7089627. DOI: 10.1183/13993003.02214-2018. View

20.

Duarte-de-Araujo A, Fonte P, Teixeira P, Hespanhol V, Correia-de-Sousa J . Is an Early Diagnosis of COPD Clinically Useful?. Arch Bronconeumol. 2022; 56(6):409-410. DOI: 10.1016/j.arbr.2019.11.012. View