Alterations in Neuromuscular Junctions and Oxidative Stress of the Soleus Muscle of Obese Wistar Rats Caused by Vibratory Platform Training

Overview

Journal J Musculoskelet Neuronal Interact

Specialties Neurology
Orthopedics
Physiology

Date 2020 Dec 3

PMID 33265086

Citations 1

Authors

Mariana Lais Boaretto

Barbara Zanardini de Andrade

Jhyslayne Ignacia Hoff Nunes Maciel

Mylena de Campos Oliveira

Camila Maria Toigo de Oliveira

Ana Tereza Bittencourt Guimaraes

Marcia Miranda Torrejais

Sara Cristina Sagae Schneider

Lucineia de Fatima Chasko Ribeiro

Gladson Ricardo Flor Bertolini

Affiliations

Soon will be listed here.

Abstract

Objectives: evaluate the effects that whole-body vibration (WBV) causes on the neuromuscular junctions and oxidative stress of the soleus muscle of obese rats.

Methods: 32 male rats were used, 16 of which were obesity induced by monosodium glutamate, randomized into four groups: control (GC), control with WBV (GCP), obese (GO) and obese with WBV (GOP). At the 70 days old, the training on WBV was started, performed 3 times a week, during 8 consecutive weeks. At the 130 days old, the animals were euthanized and the soleus muscles were collected.

Results: Regarding the analysis of the neuromuscular junctions, the obese groups had lower mean size when compared to the control groups. On the other hand, the WBV presented higher averages when compared to the groups that did not perform the training. Regarding the oxidative stress, for the lipid peroxidation there was a significant difference between obese and non-obese animals, however, there was no difference between the animals WBV and those who did not.

Conclusion: WBV promotes beneficial changes such as increased measurements of the structures of the neuromuscular junctions, but is not able to promote changes in the concentration of the cholinesterase enzyme in the synaptic cleft.

Citing Articles

An Early and Sustained Inflammatory State Induces Muscle Changes and Establishes Obesogenic Characteristics in Wistar Rats Exposed to the MSG-Induced Obesity Model.

Zazula M, Saraiva D, Theodoro J, Maciel M, Sepulveda E, Zanardini de Andrade B Int J Mol Sci. 2023; 24(5).

PMID: 36902158 PMC: 10003260. DOI: 10.3390/ijms24054730.

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