Oxidative Stress and Decreased Tissue HSP70 Are Involved in the Genesis of Sepsis: HSP70 As a Therapeutic Target

Overview

Journal Rev Bras Ter Intensiva

Specialties Critical Care
General Medicine

Date 2020 Dec 2

PMID 33263705

Citations 4

Authors

Maicon Machado Sulzbacher

Mirna Stela Ludwig

Thiago Gomes Heck

Affiliations

Soon will be listed here.

Abstract

Sepsis is a systemic infection that causes multiple organ dysfunction. HSP70 is a protein responsive to cell stress, in particular oxidative stress. Therefore, this literature review sought to investigate the roles of HSP70 and oxidative stress in the pathophysiology of sepsis and the possibility of HSP70 as a therapeutic target. HSP70 exerts a protective effect when located in cells (iHSP70), and its decrease, as well as its increase in the extracellular environment (eHSP70), under oxidative stress is a biomarker of sepsis severity. In addition, therapies that increase iHSP70 and treatment with HSP70 promote sepsis improvement.

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