The Insular Cortex As a Vestibular Area in Relation to Autonomic Function

Overview

Journal Clin Auton Res

Date 2020 Dec 1

PMID 33259005

Citations 10

Authors

Michiaki Nagai

Verena Scheper

Thomas Lenarz

Carola Y Forster

Affiliations

Soon will be listed here.

Abstract

The forebrain cerebral network including the insular cortex plays a crucial role in the regulation of the central autonomic nervous system in relation to emotional stress. Numerous studies have recently shown that the insular cortex also has roles as a vestibular area in addition to auditory function. In this review, we summarize the recent literature regarding the relationship between the insular cortex and vestibular function, and we describe our hypothesis that the insular cortex has a pivotal role in vestibular-cardiovascular integration.

Citing Articles

Vestibular stimulation and space-time interaction affect the perception of time during whole-body rotations.

Navarro Morales D, Laplanche A, Kuldavletova O, Cantave B, Kola A, Freret T PLoS One. 2025; 20(1):e0313219.

PMID: 39813243 PMC: 11734920. DOI: 10.1371/journal.pone.0313219.

Causal relationships between cortical brain structural alterations and migraine subtypes: a bidirectional Mendelian randomization study of 2,347 neuroimaging phenotypes.

Sun Z, Liu M, Zhao G, Zhang Z, Xu J, Song L J Headache Pain. 2024; 25(1):186.

PMID: 39468451 PMC: 11514853. DOI: 10.1186/s10194-024-01896-y.

Cell-Type-Specific Expression of Leptin Receptors in the Mouse Forebrain.

Canepa C, Kara J, Lee C Int J Mol Sci. 2024; 25(18).

PMID: 39337341 PMC: 11432612. DOI: 10.3390/ijms25189854.

Exploring physiological stress response evoked by passive translational acceleration in healthy adults: a pilot study utilizing electrodermal activity and heart rate variability measurements.

Yu X, Lu J, Liu W, Cheng Z, Xiao G Sci Rep. 2024; 14(1):11349.

PMID: 38762532 PMC: 11102551. DOI: 10.1038/s41598-024-61656-5.

Peripheral vertigo and subsequent risk of depression and anxiety disorders: a prospective cohort study using the UK Biobank.

Chen X, Wei D, Fang F, Song H, Yin L, Kaijser M BMC Med. 2024; 22(1):63.

PMID: 38336700 PMC: 10858592. DOI: 10.1186/s12916-023-03179-w.

References

Benarroch E . Insular cortex: Functional complexity and clinical correlations. Neurology. 2019; 93(21):932-938. DOI: 10.1212/WNL.0000000000008525. View

Butti C, Hof P . The insular cortex: a comparative perspective. Brain Struct Funct. 2010; 214(5-6):477-93. DOI: 10.1007/s00429-010-0264-y. View

Nagai M, Kishi K, Kato S . Insular cortex and neuropsychiatric disorders: a review of recent literature. Eur Psychiatry. 2007; 22(6):387-94. DOI: 10.1016/j.eurpsy.2007.02.006. View

Nagai M, Hoshide S, Kario K . The insular cortex and cardiovascular system: a new insight into the brain-heart axis. J Am Soc Hypertens. 2010; 4(4):174-82. DOI: 10.1016/j.jash.2010.05.001. View

Ture U, YASARGIL M, Al-Mefty O, Yasargil D . Arteries of the insula. J Neurosurg. 2000; 92(4):676-87. DOI: 10.3171/jns.2000.92.4.0676. View

Nagai M, Dote K, Kato M, Sasaki S, Oda N, Kagawa E . The Insular Cortex and Takotsubo Cardiomyopathy. Curr Pharm Des. 2016; 23(6):879-888. DOI: 10.2174/1381612822666161006123530. View

Critchley H . Neural mechanisms of autonomic, affective, and cognitive integration. J Comp Neurol. 2005; 493(1):154-66. DOI: 10.1002/cne.20749. View

Dieterich M, Brandt T . Perception of Verticality and Vestibular Disorders of Balance and Falls. Front Neurol. 2019; 10:172. PMC: 6457206. DOI: 10.3389/fneur.2019.00172. View

Dieterich M, Bense S, Lutz S, Drzezga A, Stephan T, Bartenstein P . Dominance for vestibular cortical function in the non-dominant hemisphere. Cereb Cortex. 2003; 13(9):994-1007. DOI: 10.1093/cercor/13.9.994. View

10.

Naidich T, Kang E, Fatterpekar G, Delman B, Gultekin S, Wolfe D . The insula: anatomic study and MR imaging display at 1.5 T. AJNR Am J Neuroradiol. 2004; 25(2):222-32. PMC: 7974606. View

11.

Ture U, Yasargil D, Al-Mefty O, YASARGIL M . Topographic anatomy of the insular region. J Neurosurg. 1999; 90(4):720-33. DOI: 10.3171/jns.1999.90.4.0720. View

12.

Macey P, Wu P, Kumar R, Ogren J, Richardson H, Woo M . Differential responses of the insular cortex gyri to autonomic challenges. Auton Neurosci. 2012; 168(1-2):72-81. PMC: 4077282. DOI: 10.1016/j.autneu.2012.01.009. View

13.

AUGUSTINE J . The insular lobe in primates including humans. Neurol Res. 1985; 7(1):2-10. DOI: 10.1080/01616412.1985.11739692. View

14.

Burton H, Jones E . The posterior thalamic region and its cortical projection in New World and Old World monkeys. J Comp Neurol. 1976; 168(2):249-301. DOI: 10.1002/cne.901680204. View

15.

Deecke L, Schwarz D, FREDRICKSON J . Nucleus ventroposterior inferior (VPI) as the ventibular thalamic relay in the rhesus monkey. I. Field potential investigation. Exp Brain Res. 1974; 20(1):88-100. DOI: 10.1007/BF00239019. View

16.

Frank S, Greenlee M . The parieto-insular vestibular cortex in humans: more than a single area?. J Neurophysiol. 2018; 120(3):1438-1450. DOI: 10.1152/jn.00907.2017. View

17.

Guldin W, Akbarian S, Grusser O . Cortico-cortical connections and cytoarchitectonics of the primate vestibular cortex: a study in squirrel monkeys (Saimiri sciureus). J Comp Neurol. 1992; 326(3):375-401. DOI: 10.1002/cne.903260306. View

18.

Brandt T, Dieterich M, Danek A . Vestibular cortex lesions affect the perception of verticality. Ann Neurol. 1994; 35(4):403-12. DOI: 10.1002/ana.410350406. View

19.

Baier B, Janzen J, Muller-Forell W, Fechir M, Muller N, Dieterich M . Pusher syndrome: its cortical correlate. J Neurol. 2011; 259(2):277-83. DOI: 10.1007/s00415-011-6173-z. View

20.

Baier B, Suchan J, Karnath H, Dieterich M . Neural correlates of disturbed perception of verticality. Neurology. 2012; 78(10):728-35. DOI: 10.1212/WNL.0b013e318248e544. View