Systematic Review and Meta-analytic Findings on the Association Between Killer-cell Immunoglobulin-like Receptor Genes and Susceptibility to Pulmonary Tuberculosis

Overview

Journal Pathog Glob Health

Specialties Infectious Diseases
Microbiology
Public Health

Date 2020 Dec 1

PMID 33258733

Citations 1

Authors

Melodi Omraninava

Sahar Mehranfar

Arezou Khosrojerdi

Sirous Jamalzehi

Jafar Karami

Morteza Motallebnezhad

Mohammad Reza Javan

Saeed Aslani

Hamed Mohammadi

Ahmad Kousha

Affiliations

Soon will be listed here.

Abstract

Several studies have evaluated the association between killer-cell immunoglobulin-like receptors (KIR) genes and susceptibility risk to tuberculosis (TB) infection. Nonetheless, their outcomes have not been conclusive and consistent. Here we implemented a systematic review and meta-analysis of KIR genes association to susceptibility risk of pulmonary TB (PTB) infection to attain a clear understanding of the involvement of these genes in susceptibility to PTB infection. A systematic search was conducted in the MEDLINE/PubMed and Scopus databases to find case-control studies published before November 2020. Pooled odds ratio (OR) and 95% confidence interval (95% CI) were calculated to determine the association between KIR genes and risk of PTB infection. After comprehensive searching and implementing the inclusion and exclusion criteria, 10 case-control studies were included in the meta-analysis. Four KIR genes were found to have significant positive association with PTB susceptibility risk of infection, including (OR = 1.454, 95% CI = 1.157-1.827; = 0.001), (OR = 1.481, 95% CI = 1.334-1.837; < 0.001), (OR = 1.782, 95% CI = 1.273-2.495; = 0.001) and (OR = 1.726, 95% CI = 1.277-2.333; < 0.001). However, the results showed that the remaining KIR genes () and two pseudogenes ( and ) did not have significant associations with risk of PTB infection. This meta-analysis provides reliable evidence that the KIR genes , and may be associated with an increased risk of PTB infection.

Citing Articles

Unveiling the Significance of HLA and KIR Diversity in Underrepresented Populations.

Santiago-Lamelas L, Castro-Santos P, Carracedo A, Olloquequi J, Diaz-Pena R Biomedicines. 2024; 12(6).

PMID: 38927540 PMC: 11202227. DOI: 10.3390/biomedicines12061333.

References

Vales-Gomez M, Reyburn H, Erskine R, Strominger J . Differential binding to HLA-C of p50-activating and p58-inhibitory natural killer cell receptors. Proc Natl Acad Sci U S A. 1998; 95(24):14326-31. PMC: 24372. DOI: 10.1073/pnas.95.24.14326. View

Tajik N, Shahsavar F, Mousavi T, Radjabzadeh M . Distribution of KIR genes in the Iranian population. Tissue Antigens. 2009; 74(1):22-31. DOI: 10.1111/j.1399-0039.2009.01263.x. View

DAmbrosio L, Tadolini M, Centis R, Duarte R, Sotgiu G, Aliberti S . Supporting clinical management of the difficult-to-treat TB cases: the ERS-WHO TB Consilium. Int J Infect Dis. 2015; 32:156-60. DOI: 10.1016/j.ijid.2014.12.024. View

Vankayalapati R, Klucar P, Wizel B, Weis S, Samten B, Safi H . NK cells regulate CD8+ T cell effector function in response to an intracellular pathogen. J Immunol. 2003; 172(1):130-7. DOI: 10.4049/jimmunol.172.1.130. View

Egger M, Davey Smith G, Schneider M, Minder C . Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997; 315(7109):629-34. PMC: 2127453. DOI: 10.1136/bmj.315.7109.629. View

Zhuang Y, Song Y, Zhu C, Zhang Y, Wang D, Nie X . Association of KIR genotypes and haplotypes with syphilis in a Chinese Han population. Scand J Immunol. 2011; 75(3):361-7. DOI: 10.1111/j.1365-3083.2011.02664.x. View

Middleton D, Gonzelez F . The extensive polymorphism of KIR genes. Immunology. 2009; 129(1):8-19. PMC: 2807482. DOI: 10.1111/j.1365-2567.2009.03208.x. View

Hsu K, Chida S, Geraghty D, Dupont B . The killer cell immunoglobulin-like receptor (KIR) genomic region: gene-order, haplotypes and allelic polymorphism. Immunol Rev. 2002; 190:40-52. DOI: 10.1034/j.1600-065x.2002.19004.x. View

Shahsavar F, Mousavi T, Azargon A, Entezami K . Association of KIR3DS1+HLA-B Bw4Ile80 combination with susceptibility to tuberculosis in Lur population of Iran. Iran J Immunol. 2012; 9(1):39-47. DOI: IJIv9i1A3. View

10.

Lu C, Shen Y, Deng Y, Wang C, Fan G, Liu Y . Association of killer cell immunoglobulin-like receptors with pulmonary tuberculosis in Chinese Han. Genet Mol Res. 2012; 11(2):1370-8. DOI: 10.4238/2012.May.15.7. View

11.

Vilches C, Rajalingam R, Uhrberg M, Gardiner C, Young N, Parham P . KIR2DL5, a novel killer-cell receptor with a D0-D2 configuration of Ig-like domains. J Immunol. 2000; 164(11):5797-804. DOI: 10.4049/jimmunol.164.11.5797. View

12.

Roy S, Barnes P, Garg A, Wu S, Cosman D, Vankayalapati R . NK cells lyse T regulatory cells that expand in response to an intracellular pathogen. J Immunol. 2008; 180(3):1729-36. DOI: 10.4049/jimmunol.180.3.1729. View

13.

Martin M, Gao X, Lee J, Nelson G, Detels R, Goedert J . Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS. Nat Genet. 2002; 31(4):429-34. DOI: 10.1038/ng934. View

14.

Vankayalapati R, Barnes P . Innate and adaptive immune responses to human Mycobacterium tuberculosis infection. Tuberculosis (Edinb). 2009; 89 Suppl 1:S77-80. DOI: 10.1016/S1472-9792(09)70018-6. View

15.

Mahfouz R, Halas H, Hoteit R, Saadeh M, Shamseddeen W, Charafeddine K . Study of KIR genes in Lebanese patients with tuberculosis. Int J Tuberc Lung Dis. 2011; 15(12):1688-91. DOI: 10.5588/ijtld.11.0138. View

16.

Shilling H, Guethlein L, Cheng N, Gardiner C, Rodriguez R, Tyan D . Allelic polymorphism synergizes with variable gene content to individualize human KIR genotype. J Immunol. 2002; 168(5):2307-15. DOI: 10.4049/jimmunol.168.5.2307. View

17.

Dhiman R, Indramohan M, Barnes P, Nayak R, Paidipally P, Rao L . IL-22 produced by human NK cells inhibits growth of Mycobacterium tuberculosis by enhancing phagolysosomal fusion. J Immunol. 2009; 183(10):6639-45. DOI: 10.4049/jimmunol.0902587. View

18.

Fathollahi A, Aslani S, Mostafaei S, Rezaei N, Mahmoudi M . The role of killer-cell immunoglobulin-like receptor (KIR) genes in susceptibility to inflammatory bowel disease: systematic review and meta-analysis. Inflamm Res. 2018; 67(9):727-736. DOI: 10.1007/s00011-018-1162-7. View

19.

Pydi S, Ramaseri Sunder S, Venkatasubramanian S, Kovvali S, Jonnalagada S, Valluri V . Killer cell immunoglobulin like receptor gene association with tuberculosis. Hum Immunol. 2012; 74(1):85-92. DOI: 10.1016/j.humimm.2012.10.006. View

20.

Tajik N, Shah-hosseini A, Mohammadi A, Jafari M, Nasiri M, Radjabzadeh M . Susceptibility to pulmonary tuberculosis in Iranian individuals is not affected by compound KIR/HLA genotype. Tissue Antigens. 2011; 79(2):90-6. DOI: 10.1111/j.1399-0039.2011.01812.x. View