Stress and the Dopaminergic Reward System

Overview

Journal Exp Mol Med

Specialties Biochemistry
Molecular Biology

Date 2020 Dec 1

PMID 33257725

Citations 100

Authors

Ja-Hyun Baik

Affiliations

Soon will be listed here.

Abstract

Dopamine regulates reward-related behavior through the mesolimbic dopaminergic pathway. Stress affects dopamine levels and dopaminergic neuronal activity in the mesolimbic dopamine system. Changes in mesolimbic dopaminergic neurotransmission are important for coping with stress, as they allow adaption to behavioral responses to various environmental stimuli. Upon stress exposure, modulation of the dopaminergic reward system is necessary for monitoring and selecting the optimal process for coping with stressful situations. Aversive stressful events may negatively regulate the dopaminergic reward system, perturbing reward sensitivity, which is closely associated with chronic stress-induced depression. The mesolimbic dopamine system is excited not only by reward but also by aversive stressful stimuli, which adds further intriguing complexity to the relationship between stress and the reward system. This review focuses on lines of evidence related to how stress, especially chronic stress, affects the mesolimbic dopamine system, and discusses the role of the dopaminergic reward system in chronic stress-induced depression.

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References

Di Chiara G . Nucleus accumbens shell and core dopamine: differential role in behavior and addiction. Behav Brain Res. 2002; 137(1-2):75-114. DOI: 10.1016/s0166-4328(02)00286-3. View

Berridge K, Robinson T . What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?. Brain Res Brain Res Rev. 1998; 28(3):309-69. DOI: 10.1016/s0165-0173(98)00019-8. View

Mangiavacchi S, Masi F, Scheggi S, Leggio B, De Montis M, Gambarana C . Long-term behavioral and neurochemical effects of chronic stress exposure in rats. J Neurochem. 2001; 79(6):1113-21. DOI: 10.1046/j.1471-4159.2001.00665.x. View

Groenewegen H, Berendse H . Connections of the subthalamic nucleus with ventral striatopallidal parts of the basal ganglia in the rat. J Comp Neurol. 1990; 294(4):607-22. DOI: 10.1002/cne.902940408. View

Berendse H, Galis-de Graaf Y, Groenewegen H . Topographical organization and relationship with ventral striatal compartments of prefrontal corticostriatal projections in the rat. J Comp Neurol. 1992; 316(3):314-47. DOI: 10.1002/cne.903160305. View

Herman J, Guillonneau D, Dantzer R, Scatton B, Le Moal M . Differential effects of inescapable footshocks and of stimuli previously paired with inescapable footshocks on dopamine turnover in cortical and limbic areas of the rat. Life Sci. 1982; 30(25):2207-14. DOI: 10.1016/0024-3205(82)90295-8. View

Willner P . Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. Psychopharmacology (Berl). 1998; 134(4):319-29. DOI: 10.1007/s002130050456. View

Usuda I, Tanaka K, Chiba T . Efferent projections of the nucleus accumbens in the rat with special reference to subdivision of the nucleus: biotinylated dextran amine study. Brain Res. 1998; 797(1):73-93. DOI: 10.1016/s0006-8993(98)00359-x. View

Gerfen C, Surmeier D . Modulation of striatal projection systems by dopamine. Annu Rev Neurosci. 2011; 34:441-66. PMC: 3487690. DOI: 10.1146/annurev-neuro-061010-113641. View

10.

Cabib S, Puglisi-Allegra S . Different effects of repeated stressful experiences on mesocortical and mesolimbic dopamine metabolism. Neuroscience. 1996; 73(2):375-80. DOI: 10.1016/0306-4522(96)00750-6. View

11.

Li X, Qi J, Yamaguchi T, Wang H, Morales M . Heterogeneous composition of dopamine neurons of the rat A10 region: molecular evidence for diverse signaling properties. Brain Struct Funct. 2012; 218(5):1159-76. DOI: 10.1007/s00429-012-0452-z. View

12.

Bessa J, Morais M, Marques F, Pinto L, Palha J, Almeida O . Stress-induced anhedonia is associated with hypertrophy of medium spiny neurons of the nucleus accumbens. Transl Psychiatry. 2013; 3:e266. PMC: 3693402. DOI: 10.1038/tp.2013.39. View

13.

Schultz W . Behavioral dopamine signals. Trends Neurosci. 2007; 30(5):203-10. DOI: 10.1016/j.tins.2007.03.007. View

14.

Khibnik L, Beaumont M, Doyle M, Heshmati M, Slesinger P, Nestler E . Stress and Cocaine Trigger Divergent and Cell Type-Specific Regulation of Synaptic Transmission at Single Spines in Nucleus Accumbens. Biol Psychiatry. 2015; 79(11):898-905. PMC: 4670821. DOI: 10.1016/j.biopsych.2015.05.022. View

15.

Ironside M, Kumar P, Kang M, Pizzagalli D . Brain mechanisms mediating effects of stress on reward sensitivity. Curr Opin Behav Sci. 2018; 22:106-113. PMC: 6195323. DOI: 10.1016/j.cobeha.2018.01.016. View

16.

Soares-Cunha C, Coimbra B, Sousa N, Rodrigues A . Reappraising striatal D1- and D2-neurons in reward and aversion. Neurosci Biobehav Rev. 2016; 68:370-386. DOI: 10.1016/j.neubiorev.2016.05.021. View

17.

Berton O, McClung C, DiLeone R, Krishnan V, Renthal W, Russo S . Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science. 2006; 311(5762):864-8. DOI: 10.1126/science.1120972. View

18.

Papp M, Klimek V, Willner P . Parallel changes in dopamine D2 receptor binding in limbic forebrain associated with chronic mild stress-induced anhedonia and its reversal by imipramine. Psychopharmacology (Berl). 1994; 115(4):441-6. DOI: 10.1007/BF02245566. View

19.

Stamford J, Muscat R, OConnor J, Patel J, Trout S, Wieczorek W . Voltammetric evidence that subsensitivity to reward following chronic mild stress is associated with increased release of mesolimbic dopamine. Psychopharmacology (Berl). 1991; 105(2):275-82. DOI: 10.1007/BF02244322. View

20.

Bloomfield M, McCutcheon R, Kempton M, Freeman T, Howes O . The effects of psychosocial stress on dopaminergic function and the acute stress response. Elife. 2019; 8. PMC: 6850765. DOI: 10.7554/eLife.46797. View