Systematic Review and Meta-analysis on the Role of Mitochondrial Cytochrome C Oxidase in Alzheimer's Disease

Overview

Journal Acta Neuropsychiatr

Publisher Cambridge University Press

Date 2020 Dec 1

PMID 33256871

Citations 12

Authors

Flavio M Morais

Angela M Ribeiro

Fabricio A Moreira

Pollyanna V G Silva

Affiliations

Soon will be listed here.

Abstract

Objective: The present study was designed to test the hypothesis that there is a reduction in the activity of the enzyme cytochrome c oxidase (Cox) in Alzheimer's disease (AD).

Methods: Systematic review of literature and meta-analysis were used with data obtained from the PubMed, Scopus, MEDLINE, Lilacs, Eric and Cochrane. The keywords were Alzheimer's AND Cox AND mitochondria; Alzheimer's AND Cox AND mitochondria; Alzheimer's AND complex IV AND mitochondria. A total of 1372 articles were found, 23 of them fitting the inclusion criteria. The data were assembled in an Excel spreadsheet and analysed using the RevMan software. A random effects model was adopted to the estimative of the effect.

Results: The data shows a significant decrease in the activity of the Cox AD patients and animal models.

Conclusion: Cox enzyme may be an important molecular component involved in the mechanisms underlying AD. Therefore, this enzyme may represent a possible new biomarker for the disease as a complementary diagnosis and a new treatment target for AD.

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