Imaging of Solid Congenital Abdominal Masses: a Review of the Literature and Practical Approach to Image Interpretation

Overview

Journal Pediatr Radiol

Specialty Pediatrics

Date 2020 Nov 30

PMID 33252758

Citations 9

Authors

Krista L Birkemeier

Affiliations

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Abstract

Fetal abdominal tumors are rare, usually benign, and cause a great deal of anxiety for expectant parents and the physicians counseling them. In this paper the author reviews the most common fetal abdominal tumors in the liver (hemangioma, mesenchymal hamartoma, hepatoblastoma, metastases) and the kidney (congenital mesoblastic nephroma, Wilms tumor, malignant rhabdoid tumor, and clear cell sarcoma), and suprarenal mass lesions (adrenal neuroblastoma, adrenal hemorrhage, and subdiaphragmatic extralobar pulmonary sequestration). The author describes the imaging approach, imaging appearance and differentiating features of tumors, and differences between fetal and childhood appearances of tumors.

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References

Amari F, Beyer D, Diedrich K, Weichert J . Fetal intra-abdominal tumors: assessment of spectrum, accuracy of prenatal diagnosis, perinatal outcome and therapy at a tertiary referral center. Eur J Obstet Gynecol Reprod Biol. 2013; 167(2):160-6. DOI: 10.1016/j.ejogrb.2012.11.023. View

Isaacs Jr H . Fetal and neonatal hepatic tumors. J Pediatr Surg. 2007; 42(11):1797-803. DOI: 10.1016/j.jpedsurg.2007.07.047. View

Marks F, Thomas P, Lustig I, Greco M, Raghavendra B, Wasserman R . In utero sonographic description of a fetal liver adenoma. J Ultrasound Med. 1990; 9(2):119-22. DOI: 10.7863/jum.1990.9.2.119. View

Applegate K, Ghei M, Perez-Atayde A . Prenatal detection of a solitary liver adenoma. Pediatr Radiol. 1999; 29(2):92-4. DOI: 10.1007/s002470050548. View

Petrikovsky B, Cohen H, Scimeca P, Bellucci E . Prenatal diagnosis of focal nodular hyperplasia of the liver. Prenat Diagn. 1994; 14(5):406-9. DOI: 10.1002/pd.1970140511. View

Demir H, Varan A, Akcoren Z, Haliloglu M, Buyukpamukcu M . Focal nodular hyperplasia of the liver and elevated alpha fetoprotein level in an infant with isolated hemihyperplasia. J Pediatr Hematol Oncol. 2008; 30(10):775-7. DOI: 10.1097/MPH.0b013e3181812c7c. View

Mo J, Dimashkieh H, Bove K . GLUT1 endothelial reactivity distinguishes hepatic infantile hemangioma from congenital hepatic vascular malformation with associated capillary proliferation. Hum Pathol. 2004; 35(2):200-9. DOI: 10.1016/j.humpath.2003.09.017. View

Johnson C, Navarro O . Clinical and sonographic features of pediatric soft-tissue vascular anomalies part 1: classification, sonographic approach and vascular tumors. Pediatr Radiol. 2017; 47(9):1184-1195. DOI: 10.1007/s00247-017-3885-y. View

Christison-Lagay E, Burrows P, Alomari A, Dubois J, Kozakewich H, Lane T . Hepatic hemangiomas: subtype classification and development of a clinical practice algorithm and registry. J Pediatr Surg. 2007; 42(1):62-7. DOI: 10.1016/j.jpedsurg.2006.09.041. View

10.

Kulungowski A, Alomari A, Chawla A, Christison-Lagay E, Fishman S . Lessons from a liver hemangioma registry: subtype classification. J Pediatr Surg. 2012; 47(1):165-70. DOI: 10.1016/j.jpedsurg.2011.10.037. View

11.

Ackermann O, Fabre M, Franchi S, Pariente D, Debray D, Jacquemin E . Widening spectrum of liver angiosarcoma in children. J Pediatr Gastroenterol Nutr. 2011; 53(6):615-9. DOI: 10.1097/MPG.0b013e318230146c. View

12.

Stringer M, Alizai N . Mesenchymal hamartoma of the liver: a systematic review. J Pediatr Surg. 2005; 40(11):1681-90. DOI: 10.1016/j.jpedsurg.2005.07.052. View

13.

Cornette J, Festen S, van den Hoonaard T, Steegers E . Mesenchymal hamartoma of the liver: a benign tumor with deceptive prognosis in the perinatal period. Case report and review of the literature. Fetal Diagn Ther. 2009; 25(2):196-202. DOI: 10.1159/000212057. View

14.

Spector L, Birch J . The epidemiology of hepatoblastoma. Pediatr Blood Cancer. 2012; 59(5):776-9. DOI: 10.1002/pbc.24215. View

15.

Herzog C, Andrassy R, Eftekhari F . Childhood cancers: hepatoblastoma. Oncologist. 2000; 5(6):445-53. DOI: 10.1634/theoncologist.5-6-445. View

16.

Trobaugh-Lotrario A, Chaiyachati B, Meyers R, Haberle B, Tomlinson G, Katzenstein H . Outcomes for patients with congenital hepatoblastoma. Pediatr Blood Cancer. 2013; 60(11):1817-25. DOI: 10.1002/pbc.24655. View

17.

Isaacs Jr H . Fetal and neonatal renal tumors. J Pediatr Surg. 2008; 43(9):1587-95. DOI: 10.1016/j.jpedsurg.2008.03.052. View

18.

Patil P, Gupta A, Gupta R, Kothari P, Kekre G, Mudkhedkar K . Unusual Presentation of Metanephric Stromal Tumor in a Neonate. Indian J Med Paediatr Oncol. 2017; 38(3):357-359. PMC: 5686983. DOI: 10.4103/ijmpo.ijmpo_27_16. View

19.

Gedikbasi A, Oztarhan K, Ulker V, Aslan G, Gul A, Sener-Arslan E . Prenatal sonographic diagnosis of tuberous sclerosis complex. J Clin Ultrasound. 2011; 39(7):427-30. DOI: 10.1002/jcu.20857. View

20.

Linam L, Yu X, Calvo-Garcia M, Rubio E, Crombleholme T, Bove K . Contribution of magnetic resonance imaging to prenatal differential diagnosis of renal tumors: report of two cases and review of the literature. Fetal Diagn Ther. 2010; 28(2):100-8. DOI: 10.1159/000313655. View