Upregulated Promotes Cancer Metastasis Via the / Pathway

Overview

Journal Mol Ther Oncolytics

Publisher Cell Press

Date 2020 Nov 30

PMID 33251331

Citations 15

Authors

Yongsheng Jia

Yujun Wang

Cuicui Zhang

Mike Yue Chen

Affiliations

Soon will be listed here.

Abstract

Metastasis is associated with poor prognosis in cancer and is a multistep process that includes invasion and migration. Several epigenetic factors are involved in this process, including chromobox protein homolog 8 (). Here, we show that is overexpressed in many cancers compared with normal tissues. Functional analyses indicated that promoted invasion and migration in glioblastoma, breast cancer, and lung cancer and . was identified as a target gene of , which interacted with the promoter to suppress expression and activity. acted as an antioncogene, and decreased levels resulted in high activity of matrix metalloprotease (MMP)-2 and , which play a central role in invasion and migration, respectively. There was a positive relationship between and activity in -modulated cell lines. In addition, negatively regulated and activity. Collectively, the results indicated that promoted invasion and migration by targeting , which resulted in increased and expression and activity. Therefore, may be a novel therapeutic target to treat metastatic cancers.

Citing Articles

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