Gastrointestinal Dysfunction in the Synucleinopathies

Overview

Journal Clin Auton Res

Date 2020 Nov 28

PMID 33247399

Citations 10

Authors

Kathryn A Chung

Ronald F Pfeiffer

Affiliations

Soon will be listed here.

Abstract

Interest in gastrointestinal dysfunction in Parkinson's disease has blossomed over the past 30 years and has generated a wealth of investigation into this non-motor aspect of the disorder, research that has encompassed its pathophysiology, its clinical features, and its impact on quality of life. The question of gastrointestinal dysfunction in the other synucleinopathies has not received nearly as much attention, but information and knowledge are growing. In this review, the current knowledge, controversies, and gaps in our understanding of the pathophysiology of gastrointestinal dysfunction in Parkinson's disease and the other synucleinopathies will be addressed, and extended focus will be directed toward the clinical problems involving saliva management, swallowing, gastric emptying, small intestinal function, and bowel function that are so problematic in these disorders.

Citing Articles

Non-Pharmacological Treatment of Autonomic Dysfunction in Parkinson's Disease and Other Synucleinopathies.

Palma J, Thijs R J Parkinsons Dis. 2023; 14(s1):S81-S92.

PMID: 37694308 PMC: 11380254. DOI: 10.3233/JPD-230173.

The Impact of Microbiota on the Gut-Brain Axis: Examining the Complex Interplay and Implications.

Chaudhry T, Senapati S, Gadam S, Mannam H, Voruganti H, Abbasi Z J Clin Med. 2023; 12(16).

PMID: 37629273 PMC: 10455396. DOI: 10.3390/jcm12165231.

Non-pharmacological and drug treatment of autonomic dysfunction in multiple system atrophy: current status and future directions.

Chen B, Yang W, Luo Y, Tan E, Wang Q J Neurol. 2023; 270(11):5251-5273.

PMID: 37477834 DOI: 10.1007/s00415-023-11876-y.

Movement Disorders and the Gut: A Review.

Talman L, Pfeiffer R Mov Disord Clin Pract. 2022; 9(4):418-428.

PMID: 35586541 PMC: 9092751. DOI: 10.1002/mdc3.13407.

Gastrointestinal Dysfunction in Parkinson's Disease.

Safarpour D, Sharzehi K, Pfeiffer R Drugs. 2022; 82(2):169-197.

PMID: 35076890 DOI: 10.1007/s40265-021-01664-1.

References

Qualman S, Haupt H, Yang P, Hamilton S . Esophageal Lewy bodies associated with ganglion cell loss in achalasia. Similarity to Parkinson's disease. Gastroenterology. 1984; 87(4):848-56. View

Spillantini M, Schmidt M, Lee V, Trojanowski J, Jakes R, Goedert M . Alpha-synuclein in Lewy bodies. Nature. 1997; 388(6645):839-40. DOI: 10.1038/42166. View

Braak H, de Vos R, Bohl J, Del Tredici K . Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology. Neurosci Lett. 2005; 396(1):67-72. DOI: 10.1016/j.neulet.2005.11.012. View

Lebouvier T, Chaumette T, Damier P, Coron E, Touchefeu Y, Vrignaud S . Pathological lesions in colonic biopsies during Parkinson's disease. Gut. 2008; 57(12):1741-3. DOI: 10.1136/gut.2008.162503. View

Shannon K, Keshavarzian A, Mutlu E, Dodiya H, Daian D, Jaglin J . Alpha-synuclein in colonic submucosa in early untreated Parkinson's disease. Mov Disord. 2011; 27(6):709-15. DOI: 10.1002/mds.23838. View

Shannon K, Keshavarzian A, Dodiya H, Jakate S, Kordower J . Is alpha-synuclein in the colon a biomarker for premotor Parkinson's disease? Evidence from 3 cases. Mov Disord. 2012; 27(6):716-9. DOI: 10.1002/mds.25020. View

Hilton D, Stephens M, Kirk L, Edwards P, Potter R, Zajicek J . Accumulation of α-synuclein in the bowel of patients in the pre-clinical phase of Parkinson's disease. Acta Neuropathol. 2013; 127(2):235-41. DOI: 10.1007/s00401-013-1214-6. View

Abbott R, Petrovitch H, White L, Masaki K, Tanner C, Curb J . Frequency of bowel movements and the future risk of Parkinson's disease. Neurology. 2001; 57(3):456-62. DOI: 10.1212/wnl.57.3.456. View

Ueki A, Otsuka M . Life style risks of Parkinson's disease: association between decreased water intake and constipation. J Neurol. 2004; 251 Suppl 7:vII18-23. DOI: 10.1007/s00415-004-1706-3. View

10.

Svensson E, Horvath-Puho E, Thomsen R, Djurhuus J, Pedersen L, Borghammer P . Vagotomy and subsequent risk of Parkinson's disease. Ann Neurol. 2015; 78(4):522-9. DOI: 10.1002/ana.24448. View

11.

Liu S, Chan P, Stoessl A . The underlying mechanism of prodromal PD: insights from the parasympathetic nervous system and the olfactory system. Transl Neurodegener. 2017; 6:4. PMC: 5319081. DOI: 10.1186/s40035-017-0074-8. View

12.

Killinger B, Madaj Z, Sikora J, Rey N, Haas A, Vepa Y . The vermiform appendix impacts the risk of developing Parkinson's disease. Sci Transl Med. 2018; 10(465). PMC: 6319259. DOI: 10.1126/scitranslmed.aar5280. View

13.

Liu B, Fang F, Ye W, Wirdefeldt K . Appendectomy, Tonsillectomy and Parkinson's Disease Risk: A Swedish Register-Based Study. Front Neurol. 2020; 11:510. PMC: 7292857. DOI: 10.3389/fneur.2020.00510. View

14.

Mendes A, Goncalves A, Vila-Cha N, Moreira I, Fernandes J, Damasio J . Appendectomy may delay Parkinson's disease Onset. Mov Disord. 2015; 30(10):1404-7. DOI: 10.1002/mds.26311. View

15.

Marras C, Lang A, Austin P, Lau C, Urbach D . Appendectomy in mid and later life and risk of Parkinson's disease: A population-based study. Mov Disord. 2016; 31(8):1243-7. DOI: 10.1002/mds.26670. View

16.

Svensson E, Horvath-Puho E, Stokholm M, Sorensen H, Henderson V, Borghammer P . Appendectomy and risk of Parkinson's disease: A nationwide cohort study with more than 10 years of follow-up. Mov Disord. 2016; 31(12):1918-1922. DOI: 10.1002/mds.26761. View

17.

Palacios N, Hughes K, Cereda E, Schwarzschild M, Ascherio A . Appendectomy and risk of Parkinson's disease in two large prospective cohorts of men and women. Mov Disord. 2018; 33(9):1492-1496. PMC: 6310901. DOI: 10.1002/mds.109. View

18.

Forsyth C, Shannon K, Kordower J, Voigt R, Shaikh M, Jaglin J . Increased intestinal permeability correlates with sigmoid mucosa alpha-synuclein staining and endotoxin exposure markers in early Parkinson's disease. PLoS One. 2011; 6(12):e28032. PMC: 3228722. DOI: 10.1371/journal.pone.0028032. View

19.

Clairembault T, Leclair-Visonneau L, Coron E, Bourreille A, Le Dily S, Vavasseur F . Structural alterations of the intestinal epithelial barrier in Parkinson's disease. Acta Neuropathol Commun. 2015; 3:12. PMC: 4353469. DOI: 10.1186/s40478-015-0196-0. View

20.

Drolet R, Cannon J, Montero L, Greenamyre J . Chronic rotenone exposure reproduces Parkinson's disease gastrointestinal neuropathology. Neurobiol Dis. 2009; 36(1):96-102. DOI: 10.1016/j.nbd.2009.06.017. View