Sperm Parameters and Anti-Müllerian Hormone Remain Stable with Helicobacter Pylori Infection: a Cross-sectional Study

Overview

Journal BMC Urol

Publisher Biomed Central

Specialty Urology

Date 2020 Nov 27

PMID 33243200

Citations 2

Authors

Chun Feng

Ping-Ping Lv

Chang-Chang Huang

Song-Qing Yang

Qiu-Ping Yao

Jin-Ming Shen

Min Jin

Affiliations

Soon will be listed here.

Abstract

Background And Aims: It has been reported that Helicobacter pylori (HP) infection was more prevalent in infertile populations. HP infection could lead to decreased sperm parameters, and treating the HP infection could improve the quality of sperm. However, studies investigating the relationship between infertility and HP infection are still limited, and more evidence is required. Therefore, we performed the present study to investigate the impact of HP infection on sperm quality in males and on ovarian reserve in females.

Methods: A total of 16,522 patients who visited the Second Hospital of Zhejiang University from January 2016 to June 2019 due to abdominal discomfort and underwent a C-urea breath HP test were included in this retrospective cross-sectional study. Among them, 565 had performed sperm analysis or ovarian reserve tests in the past three months and were involved for further analyses. Sperm parameters were examined with a computer-assisted sperm analysis system, and serum anti-Müllerian hormone (AMH) and sex hormones were tested with an electrochemiluminescence method.

Results: Among 363 patients who underwent the sperm test, 136 (37.47%) had HP infection. Among 202 patients who underwent the AMH test, 55 (27.23%) had HP infection. There was no difference in sperm concentration and motility between the HP+ and HP- groups (P > 0.05). Further subgroup analyses stratified into 5-year age groups confirmed that there was no significant difference in sperm parameters (P > 0.05). When pooled with previously published data, no significant difference in sperm concentration or motility was found (P > 0.05). Meanwhile, this study found that the serum AMH level was similar between the HP+ and HP- groups (P > 0.05). Further subgroup analyses confirmed that there was no significant difference in serum AMH level (P > 0.05).

Conclusions: There were no differences in sperm parameters and AMH levels based on history of HP infection among Chinese patients.

Citing Articles

and unignorable extragastric diseases: Mechanism and implications.

He J, Liu Y, OuYang Q, Li R, Li J, Chen W Front Microbiol. 2022; 13:972777.

PMID: 35992650 PMC: 9386483. DOI: 10.3389/fmicb.2022.972777.

Correction to: Sperm parameters and anti-Müllerian hormone remain stable with Helicobacter pylori infection: a cross-sectional study.

Feng C, Lv P, Huang C, Yang S, Yao Q, Shen J BMC Urol. 2021; 21(1):19.

PMID: 33546630 PMC: 7866649. DOI: 10.1186/s12894-021-00783-x.

References

Lau J, Ioannidis J, Schmid C . Quantitative synthesis in systematic reviews. Ann Intern Med. 1998; 127(9):820-6. DOI: 10.7326/0003-4819-127-9-199711010-00008. View

El-Garem Y, El-Sawy M, Mostafa T . Seminal Helicobacter pylori treatment improves sperm motility in infertile asthenozoospermic men. Urology. 2014; 84(6):1347-50. DOI: 10.1016/j.urology.2014.09.004. View

Kusano C, Gotoda T, Ikehara H, Suzuki S, Shibuya H, Horii T . The Accuracy of the Serum Antibody Test for Helicobacter pylori Infection among Junior High School Students. Digestion. 2019; 102(2):155-160. DOI: 10.1159/000502900. View

Abbara A, Eng P, Phylactou M, Clarke S, Hunjan T, Roberts R . Anti-Müllerian hormone (AMH) in the Diagnosis of Menstrual Disturbance Due to Polycystic Ovarian Syndrome. Front Endocrinol (Lausanne). 2019; 10:656. PMC: 6775233. DOI: 10.3389/fendo.2019.00656. View

Collodel G, Moretti E, Campagna M, Capitani S, Lenzi C, Figura N . Infection by CagA-positive Helicobacter pylori strains may contribute to alter the sperm quality of men with fertility disorders and increase the systemic levels of TNF-alpha. Dig Dis Sci. 2009; 55(1):94-100. DOI: 10.1007/s10620-008-0704-1. View

Hansen K, Hodnett G, Knowlton N, Craig L . Correlation of ovarian reserve tests with histologically determined primordial follicle number. Fertil Steril. 2010; 95(1):170-5. DOI: 10.1016/j.fertnstert.2010.04.006. View

Park J, Forman D, Waskito L, Yamaoka Y, Crabtree J . Epidemiology of and CagA-Positive Infections and Global Variations in Gastric Cancer. Toxins (Basel). 2018; 10(4). PMC: 5923329. DOI: 10.3390/toxins10040163. View

Miftahussurur M . Noninvasive Helicobacter pylori Diagnostic Methods in Indonesia. Gut Liver. 2019; 14(5):553-559. PMC: 7492493. DOI: 10.5009/gnl19264. View

Hajishafiha M, Ghasemi-Rad M, Memari A, Naji S, Mladkova N, Saeedi V . Effect of Helicobacter pylori infection on pregnancy rates and early pregnancy loss after intracytoplasmic sperm injection. Int J Womens Health. 2011; 3:329-35. PMC: 3220315. DOI: 10.2147/IJWH.S24424. View

10.

Moretti E, Figura N, Campagna M, Iacoponi F, Gonnelli S, Collodel G . Infectious Burden and Semen Parameters. Urology. 2016; 100:90-96. DOI: 10.1016/j.urology.2016.10.032. View

11.

Li N, Tang B, Jia Y, Zhu P, Zhuang Y, Fang Y . CagA Protein Negatively Regulates Autophagy and Promotes Inflammatory Response via c-Met-PI3K/Akt-mTOR Signaling Pathway. Front Cell Infect Microbiol. 2017; 7:417. PMC: 5613121. DOI: 10.3389/fcimb.2017.00417. View

12.

Horvat A, Noto J, Ramatchandirin B, Zaika E, Palrasu M, Wei J . Helicobacter pylori pathogen regulates p14ARF tumor suppressor and autophagy in gastric epithelial cells. Oncogene. 2018; 37(37):5054-5065. PMC: 6138561. DOI: 10.1038/s41388-018-0343-8. View

13.

Moretti E, Figura N, Campagna M, Gonnelli S, Iacoponi F, Collodel G . Sperm Parameters and Semen Levels of Inflammatory Cytokines in Helicobacter pylori-infected Men. Urology. 2015; 86(1):41-6. DOI: 10.1016/j.urology.2015.02.068. View

14.

Teede H, Misso M, Tassone E, Dewailly D, Ng E, Azziz R . Anti-Müllerian Hormone in PCOS: A Review Informing International Guidelines. Trends Endocrinol Metab. 2019; 30(7):467-478. DOI: 10.1016/j.tem.2019.04.006. View

15.

Calzada M, Lopez N, Noguera J, Mendiola J, Hernandez A, Corbalan S . AMH in combination with SHBG for the diagnosis of polycystic ovary syndrome. J Obstet Gynaecol. 2019; 39(8):1130-1136. DOI: 10.1080/01443615.2019.1587604. View

16.

Razuka-Ebela D, Giupponi B, Franceschi F . Helicobacter pylori and extragastric diseases. Helicobacter. 2018; 23 Suppl 1:e12520. DOI: 10.1111/hel.12520. View

17.

Yin L, Liu F, Guo C, Wang Q, Pan K, Xu L . Analysis of virulence diversity of 73 Helicobacter pylori strains isolated in Guizhou province, China. Mol Med Rep. 2018; 18(5):4611-4620. DOI: 10.3892/mmr.2018.9462. View

18.

Moretti E, Collodel G, Mazzi L, Campagna M, Figura N . CagA-positive Helicobacter pylori infection and reduced sperm motility, vitality, and normal morphology. Dis Markers. 2013; 35(4):229-34. PMC: 3780520. DOI: 10.1155/2013/919174. View

19.

Sanchez-Alvarez J, Cano-Corres R, Fuentes-Arderiu X . A Complement for the WHO Laboratory Manual for the Examination and Processing of Human Semen (First Edition, 2010). EJIFCC. 2016; 23(3):103-6. PMC: 4975259. View

20.

Luo D, Wan X, Liu J, Tong T . Optimally estimating the sample mean from the sample size, median, mid-range, and/or mid-quartile range. Stat Methods Med Res. 2016; 27(6):1785-1805. DOI: 10.1177/0962280216669183. View