» Articles » PMID: 33240941

Current State of the Art in Ventricle Tissue Engineering

Overview
Date 2020 Nov 26
PMID 33240941
Citations 2
Authors
Affiliations
Soon will be listed here.
Abstract

The field of ventricle tissue engineering is focused on bioengineering highly functioning left ventricles that can be used as model systems for basic cardiology research and for cardiotoxicity testing. In this article, we review the current state of the art in the field of ventricle tissue engineering and discuss different strategies that have been used to bioengineer ventricles. Based on this body of literature, there are now common themes in the field that provide guidance for future directives, also presented in this article.

Citing Articles

Development of Novel 3D Spheroids for Discrete Subaortic Stenosis.

Brimmer S, Ji P, Birla R, Heinle J, Grande-Allen J, Keswani S Cardiovasc Eng Technol. 2024; 15(6):704-715.

PMID: 39495395 DOI: 10.1007/s13239-024-00746-x.


Recent advances in biological pumps as a building block for bioartificial hearts.

Brimmer S, Ji P, Birla A, Keswani S, Caldarone C, Birla R Front Bioeng Biotechnol. 2023; 11:1061622.

PMID: 36741765 PMC: 9895798. DOI: 10.3389/fbioe.2023.1061622.

References
1.
Birla R, Huang Y, Dennis R . Development of a novel bioreactor for the mechanical loading of tissue-engineered heart muscle. Tissue Eng. 2007; 13(9):2239-48. DOI: 10.1089/ten.2006.0359. View

2.
Patel N, Birla R . The Bioengineered Cardiac Left Ventricle. ASAIO J. 2017; 64(1):56-62. DOI: 10.1097/MAT.0000000000000642. View

3.
Markou M, Kouroupis D, Badounas F, Katsouras A, Kyrkou A, Fotsis T . Tissue Engineering Using Vascular Organoids From Human Pluripotent Stem Cell Derived Mural Cell Phenotypes. Front Bioeng Biotechnol. 2020; 8:278. PMC: 7182037. DOI: 10.3389/fbioe.2020.00278. View

4.
Li R, Keung W, Cashman T, Backeris P, Johnson B, Bardot E . Bioengineering an electro-mechanically functional miniature ventricular heart chamber from human pluripotent stem cells. Biomaterials. 2018; 163:116-127. PMC: 6561506. DOI: 10.1016/j.biomaterials.2018.02.024. View

5.
Zhang Y, Arneri A, Bersini S, Shin S, Zhu K, Goli-Malekabadi Z . Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip. Biomaterials. 2016; 110:45-59. PMC: 5198581. DOI: 10.1016/j.biomaterials.2016.09.003. View