Definition and Review on a Category of Long Non-coding RNA: Atherosclerosis-associated Circulating LncRNA (ASCLncRNA)

Overview

Journal PeerJ

Specialties Biology
Environmental Health
General Medicine

Date 2020 Nov 26

PMID 33240586

Citations 3

Authors

Shanshan Lu

Qin Liang

Yanqing Huang

Fanming Meng

Junwen Liu

Affiliations

Soon will be listed here.

Abstract

Atherosclerosis (AS) is one of the most common cardiovascular system diseases which seriously affects public health in modern society. Finding potential biomarkers in the complicated pathological progression of AS is of great significance for the prevention and treatment of AS. Studies have shown that long noncoding RNAs (lncRNAs) can be widely involved in the regulation of many physiological processes, and have important roles in different stages of AS formation. LncRNAs can be secreted into the circulatory system through exosomes, microvesicles, and apoptotic bodies. Recently, increasing studies have been focused on the relationships between circulating lncRNAs and AS development. The lncRNAs in circulating blood are expected to be new non-invasive diagnostic markers for monitoring the progression of AS. We briefly reviewed the previously reported lncRNA transcripts which related to AS development and detectable in circulating blood, including , , , , -, , , , , , , , and . Further researches and a definition of atherosclerosis-associated circulating lncRNA (ASCLncRNA) were also discussed.

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