Combinations of Modifiable Lifestyle Behaviours in Relation to Colorectal Cancer Risk in Alberta's Tomorrow Project

Overview

Journal Sci Rep

Specialty Science

Date 2020 Nov 26

PMID 33239697

Citations 6

Authors

Dylan E OSullivan

Amy Metcalfe

Troy W R Hillier

Will D King

Sangmin Lee

Joy Pader

Darren R Brenner

Affiliations

Soon will be listed here.

Abstract

The objective of this study was to identify distinct clusters of individuals that exhibit unique patterns of modifiable lifestyle-related behaviours and to determine how these patterns are associated with the risk of developing colorectal cancer (CRC). The study consisted of 26,460 participants and 267 CRC cases from Alberta's Tomorrow Project. Exploratory latent class analysis of risk behaviours (obesity, physical inactivity, meat consumption, smoking, alcohol consumption, and fruit and vegetable consumption) and Cox proportional hazard models were utilized. Seven unique behavioural groups were identified, where the risk of CRC was 2.34 to 2.87 times greater for high risk groups compared to the low risk group. Sex-specific models identified higher risk groups among men (Hazard Ratios [HRs]: 3.15 to 3.89) than among women (HRs: 1.99 to 2.19). Targeting groups defined by clustering of behaviours could potentially lead to more effective prevention of CRC on a population level.

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