Combination Therapy to Treat Fungal Biofilm-Based Infections

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2020 Nov 26

PMID 33238622

Citations 20

Authors

Jana Tits

Bruno P A Cammue

Karin Thevissen

Affiliations

Soon will be listed here.

Abstract

An increasing number of people is affected by fungal biofilm-based infections, which are resistant to the majority of currently-used antifungal drugs. Such infections are often caused by species from the genera or Only a few antifungal drugs, including echinocandins and liposomal formulations of amphotericin B, are available to treat such biofilm-based fungal infections. This review discusses combination therapy as a novel antibiofilm strategy. More specifically, in vitro methods to discover new antibiofilm combinations will be discussed. Furthermore, an overview of the main modes of action of promising antibiofilm combination treatments will be provided as this knowledge may facilitate the optimization of existing antibiofilm combinations or the development of new ones with a similar mode of action.

Citing Articles

Trichosporon infection in chronic kidney disease patients from a tertiary care hospital - a case series or an outbreak? An unanswered question but a well-managed problem.

Hassan H, Nair L A, N S V, R J, Reghukumar A, M C S GMS Infect Dis. 2024; 12:Doc05.

PMID: 39669586 PMC: 11636554. DOI: 10.3205/id000090.

Inhibition of Development and Metabolism of Dual-Species Biofilms of and () by Organoselenium Compounds.

Calvi G, Cartaxo G, Carretoni Q, da Silva A, de Moraes D, Pradella J Pharmaceuticals (Basel). 2024; 17(8).

PMID: 39204183 PMC: 11359205. DOI: 10.3390/ph17081078.

Risk factors for short-term prognosis of end-stage liver disease complicated by invasive pulmonary aspergillosis.

Yu W, Xiao Y, Luo Y, Hu Y, Ji R, Wang W Eur J Clin Microbiol Infect Dis. 2024; 43(4):713-721.

PMID: 38347245 DOI: 10.1007/s10096-024-04775-1.

Comparative analysis of the biological characteristics and mechanisms of azole resistance of clinical strains.

Zeng M, Zhou X, Yang C, Liu Y, Zhang J, Xin C Front Microbiol. 2023; 14:1253197.

PMID: 38029222 PMC: 10665732. DOI: 10.3389/fmicb.2023.1253197.

Design, Synthesis, and Biological Evaluation of '-Phenylhydrazides as Potential Antifungal Agents.

Zhu P, Zheng J, Yan J, Li Z, Li X, Geng H Int J Mol Sci. 2023; 24(20).

PMID: 37894800 PMC: 10606473. DOI: 10.3390/ijms242015120.

References

Liu Y, Ren H, Wang D, Zhang M, Sun S, Zhao Y . The synergistic antifungal effects of gypenosides combined with fluconazole against resistant Candida albicans via inhibiting the drug efflux and biofilm formation. Biomed Pharmacother. 2020; 130:110580. DOI: 10.1016/j.biopha.2020.110580. View

Sanglard D, Ischer F, Marchetti O, Entenza J, Bille J . Calcineurin A of Candida albicans: involvement in antifungal tolerance, cell morphogenesis and virulence. Mol Microbiol. 2003; 48(4):959-76. DOI: 10.1046/j.1365-2958.2003.03495.x. View

Ramage G, VandeWalle K, Lopez-Ribot J, Wickes B . The filamentation pathway controlled by the Efg1 regulator protein is required for normal biofilm formation and development in Candida albicans. FEMS Microbiol Lett. 2002; 214(1):95-100. DOI: 10.1111/j.1574-6968.2002.tb11330.x. View

Lamoth F, Juvvadi P, Gehrke C, Steinbach W . In vitro activity of calcineurin and heat shock protein 90 Inhibitors against Aspergillus fumigatus azole- and echinocandin-resistant strains. Antimicrob Agents Chemother. 2012; 57(2):1035-9. PMC: 3553695. DOI: 10.1128/AAC.01857-12. View

Lee M, Geller A, Bamford N, Liu H, Gravelat F, Snarr B . Deacetylation of Fungal Exopolysaccharide Mediates Adhesion and Biofilm Formation. mBio. 2016; 7(2):e00252-16. PMC: 4817252. DOI: 10.1128/mBio.00252-16. View

Sangalli-Leite F, Scorzoni L, de Paula E Silva A, da Silva J, de Oliveira H, Singulani J . Synergistic effect of pedalitin and amphotericin B against Cryptococcus neoformans by in vitro and in vivo evaluation. Int J Antimicrob Agents. 2016; 48(5):504-511. DOI: 10.1016/j.ijantimicag.2016.07.025. View

Li X, Yu C, Huang X, Sun S . Synergistic Effects and Mechanisms of Budesonide in Combination with Fluconazole against Resistant Candida albicans. PLoS One. 2016; 11(12):e0168936. PMC: 5179115. DOI: 10.1371/journal.pone.0168936. View

Lu M, Yan H, Yu C, Yuan L, Sun S . Proton pump inhibitors act synergistically with fluconazole against resistant Candida albicans. Sci Rep. 2020; 10(1):498. PMC: 6965112. DOI: 10.1038/s41598-019-57174-4. View

Ernst E, Klepser M, Pfaller M . In vitro interaction of fluconazole and amphotericin B administered sequentially against Candida albicans: effect of concentration and exposure time. Diagn Microbiol Infect Dis. 1999; 32(3):205-10. DOI: 10.1016/s0732-8893(98)00099-6. View

10.

Watson P, Rose M, Ellis S, England H, Kelly S . Defective sterol C5-6 desaturation and azole resistance: a new hypothesis for the mode of action of azole antifungals. Biochem Biophys Res Commun. 1989; 164(3):1170-5. DOI: 10.1016/0006-291x(89)91792-0. View

11.

Wagner C, Graninger W, Presterl E, Joukhadar C . The echinocandins: comparison of their pharmacokinetics, pharmacodynamics and clinical applications. Pharmacology. 2006; 78(4):161-77. DOI: 10.1159/000096348. View

12.

Bugli F, Posteraro B, Papi M, Torelli R, Maiorana A, Paroni Sterbini F . In vitro interaction between alginate lyase and amphotericin B against Aspergillus fumigatus biofilm determined by different methods. Antimicrob Agents Chemother. 2012; 57(3):1275-82. PMC: 3591909. DOI: 10.1128/AAC.01875-12. View

13.

Juvvadi P, Lamoth F, Steinbach W . Calcineurin-mediated regulation of hyphal growth, septation, and virulence in Aspergillus fumigatus. Mycopathologia. 2014; 178(5-6):341-8. PMC: 4239173. DOI: 10.1007/s11046-014-9794-9. View

14.

Ibrahim A, Mirbod F, Filler S, Banno Y, Cole G, Kitajima Y . Evidence implicating phospholipase as a virulence factor of Candida albicans. Infect Immun. 1995; 63(5):1993-8. PMC: 173255. DOI: 10.1128/iai.63.5.1993-1998.1995. View

15.

Walraven C, Lee S . Antifungal lock therapy. Antimicrob Agents Chemother. 2012; 57(1):1-8. PMC: 3535896. DOI: 10.1128/AAC.masthead.57-1. View

16.

Siekierka J, Sigal N . FK-506 and cyclosporin A: immunosuppressive mechanism of action and beyond. Curr Opin Immunol. 1992; 4(5):548-52. DOI: 10.1016/0952-7915(92)90024-9. View

17.

Shrestha S, Tuladhar N, Basnyat S, Acharya G, Shrestha P, Kumar P . Prevalence of vaginitis among pregnant women attending Paropakar Maternity and Women's Hospital, Thapathali, Kathmandu, Nepal. Nepal Med Coll J. 2012; 13(4):293-6. View

18.

Khan A, Alanazi A, Jabeen M, Khan S, Malik A . Additive potential of combination therapy against cryptococcosis employing a novel amphotericin B and fluconazole loaded dual delivery system. Eur J Pharm Sci. 2018; 119:171-178. DOI: 10.1016/j.ejps.2018.04.015. View

19.

Kaneko Y, Fukazawa H, Ohno H, Miyazaki Y . Combinatory effect of fluconazole and FDA-approved drugs against Candida albicans. J Infect Chemother. 2013; 19(6):1141-5. DOI: 10.1007/s10156-013-0639-0. View

20.

Hoyer L, Green C, Oh S, Zhao X . Discovering the secrets of the Candida albicans agglutinin-like sequence (ALS) gene family--a sticky pursuit. Med Mycol. 2007; 46(1):1-15. PMC: 2742883. DOI: 10.1080/13693780701435317. View