Cyst Reduction by Melatonin in a Novel Model of Polycystic Kidney Disease

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2020 Nov 26

PMID 33238462

Citations 5

Authors

Cassandra Millet-Boureima

Roman Rozencwaig

Felix Polyak

Chiara Gamberi

Affiliations

Soon will be listed here.

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) causes progressive cystic degeneration of the renal tubules, the nephrons, eventually severely compromising kidney function. ADPKD is incurable, with half of the patients eventually needing renal replacement. Treatments for ADPKD patients are limited and new effective therapeutics are needed. Melatonin, a central metabolic regulator conserved across all life kingdoms, exhibits oncostatic and oncoprotective activity and no detected toxicity. Here, we used the () model of polycystic kidney disease to test the cyst-reducing potential of melatonin. Significant cyst reduction was found in the renal (Malpighian) tubules upon melatonin administration and suggest mechanistic sophistication. Similar to vertebrate PKD, the fly PKD model responds to the antiproliferative drugs rapamycin and mimics of the second mitochondria-derived activator of caspases (Smac). Melatonin appears to be a new cyst-reducing molecule with attractive properties as a potential candidate for PKD treatment.

Citing Articles

Melatonin Alleviates Acute Kidney Injury by Inhibiting NRF2/Slc7a11 Axis-Mediated Ferroptosis.

Huang Y, Jiang L, Liu X, Wang X, Gao L, Zeng H Oxid Med Cell Longev. 2022; 2022:4776243.

PMID: 35979396 PMC: 9377938. DOI: 10.1155/2022/4776243.

Melatonin attenuates radiation-induced cortical bone-derived stem cells injury and enhances bone repair in postradiation femoral defect model.

Hu W, Liang J, Liao S, Zhao Z, Wang Y, Mao X Mil Med Res. 2021; 8(1):61.

PMID: 34895335 PMC: 8666036. DOI: 10.1186/s40779-021-00355-y.

Empowering Melatonin Therapeutics with Models.

Millet-Boureima C, Ennis C, Jamison J, McSweeney S, Park A, Gamberi C Diseases. 2021; 9(4).

PMID: 34698120 PMC: 8544433. DOI: 10.3390/diseases9040067.

Modeling Neoplastic Growth in Renal Cell Carcinoma and Polycystic Kidney Disease.

Millet-Boureima C, He S, Le T, Gamberi C Int J Mol Sci. 2021; 22(8).

PMID: 33920158 PMC: 8070407. DOI: 10.3390/ijms22083918.

Anti-Warburg Effect of Melatonin: A Proposed Mechanism to Explain its Inhibition of Multiple Diseases.

Reiter R, Sharma R, Rosales-Corral S Int J Mol Sci. 2021; 22(2).

PMID: 33466614 PMC: 7828708. DOI: 10.3390/ijms22020764.

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