The Escherichia Coli Cell Division Proteins FtsY, FtsE and FtsX Are Inner Membrane-associated

Overview

Journal Mol Gen Genet

Specialties Genetics
Molecular Biology

Date 1987 Dec 1

PMID 3323846

Citations 22

Authors

D R Gill

G P Salmond

Affiliations

Soon will be listed here.

Abstract

The cell division genes ftsY, ftsE and ftsX form an operon mapping at 76 min on the Escherichia coli chromosome. The protein products of these genes have been identified previously. We have studied the cellular location of the radiolabelled Fts proteins using maxicells and standard fractionation procedures. Previous protein sequence homologies suggested an inner membrane location for FtsE. We have confirmed this predicted location and have shown that FtsY and FtsX are also inner membrane-associated. These results are in agreement with the hypothesis that FtsE may act at the inner membrane, in a "septalsome" complex, by coupling ATP hydrolysis to the process of bacterial cell division.

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