Tumorigenic De-differentiation: the Alternative Splicing Way

Overview

Journal Mol Cell Oncol

Specialty Oncology

Date 2020 Nov 25

PMID 33235913

Authors

Debleena Ray

David M Epstein

Affiliations

Soon will be listed here.

Abstract

The mechanism of acquisition of tumorigenic properties by somatic cells at the onset of cancer and later during relapse is a question of paramount importance in cancer biology. We have recently discovered a Muscleblind like-1 (MBNL1)-driven alternative-splicing mediated mechanism of tumorigenic de-differentiation that is associated with poor prognosis, relapse and metastasis in common cancer types.

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