Casticin Improves Respiratory Dysfunction and Attenuates Oxidative Stress and Inflammation Via Inhibition of NF-ĸB in a Chronic Obstructive Pulmonary Disease Model of Chronic Cigarette Smoke-Exposed Rats

Overview

Journal Drug Des Devel Ther

Specialty Pharmacology

Date 2020 Nov 25

PMID 33235440

Citations 8

Authors

Jie Li

Chen Qiu

Peng Xu

Yongzhen Lu

Rongchang Chen

Affiliations

Soon will be listed here.

Abstract

Objective: The present study was conducted to elucidate the protective effect of Casticin against chronic obstructive pulmonary disease (COPD) in rats.

Methods: The COPD in rats was induced by the controlled cigarette smoke, and CST (10, 20, and 30 mg/kg) was injected into the cigarette-smoke exposed rats. Blood was taken from the abdominal vein and centrifuged (1500×g, 4°C, 15min); plasma was collected and used for the determination of various biochemical parameters.

Results: The results of the study suggested that CST significantly improved the lung functions of the rats in a dose-dependent manner. It also causes a reduction of white blood cells, neutrophils, and macrophages in BALF of rats. The plasma level of leptin and C-reactive protein together with pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) were also significantly restored to near to normal in CST-treated group. In Western blot analysis, CST causes significant inhibition of the NF-ĸB and iNOS pathway.

Conclusion: Our study demonstrated that the CST protects lungs against COPD via improving lung functions and inhibition of oxidative stress and inflammation.

Citing Articles

Jing Si Herbal Tea Modulates Macrophage Polarization and Inflammatory Signaling in LPS-Induced Inflammation.

Wei M, Huang K, Kang H, Liu G, Kuo C, Tzeng I Int J Med Sci. 2024; 21(15):3046-3057.

PMID: 39628684 PMC: 11610342. DOI: 10.7150/ijms.100720.

Chemical profiling and mechanisms of Agarikon pill in a rat model of cigarette smoke-induced chronic obstructive pulmonary disease.

Keremu A, Talat Z, Lu X, Abdulla R, Habasi M, Aisa H J Tradit Complement Med. 2024; 14(5):477-493.

PMID: 39262658 PMC: 11384093. DOI: 10.1016/j.jtcme.2024.03.006.

Polyphenols as Therapeutics in Respiratory Diseases: Moving from Preclinical Evidence to Potential Clinical Applications.

Emran T, Eva T, Zehravi M, Islam F, Khan J, Kareemulla S Int J Biol Sci. 2024; 20(8):3236-3256.

PMID: 38904027 PMC: 11186353. DOI: 10.7150/ijbs.93875.

Anti-osteoporosis activity of casticin in ovariectomized rats.

Zhang D, Li J, Li X, Liu W, Yu Y, Sun H Toxicol Res (Camb). 2024; 13(2):tfae064.

PMID: 38680951 PMC: 11052697. DOI: 10.1093/toxres/tfae064.

Casticin suppresses RANKL‑induced osteoclastogenesis and prevents ovariectomy‑induced bone loss by regulating the AKT/ERK and NF‑κB signaling pathways.

Yang F, Su Y, Liang J, Wang K, Lian H, Chen J Int J Mol Med. 2023; 51(5).

PMID: 37052260 PMC: 10198048. DOI: 10.3892/ijmm.2023.5246.

References

Song X, Zhang Y, Wang X, Zhang W, Wang Z, Zhang F . Casticin induces apoptosis and G0/G1 cell cycle arrest in gallbladder cancer cells. Cancer Cell Int. 2017; 17:9. PMC: 5217413. DOI: 10.1186/s12935-016-0377-3. View

Auerbach A, Hernandez M . The effect of environmental oxidative stress on airway inflammation. Curr Opin Allergy Clin Immunol. 2012; 12(2):133-9. PMC: 3319111. DOI: 10.1097/ACI.0b013e32835113d6. View

Kirkham P, Rahman I . Oxidative stress in asthma and COPD: antioxidants as a therapeutic strategy. Pharmacol Ther. 2006; 111(2):476-94. DOI: 10.1016/j.pharmthera.2005.10.015. View

Liu Y, Zou X, Chai Y, Yao Y . Macrophage polarization in inflammatory diseases. Int J Biol Sci. 2014; 10(5):520-9. PMC: 4046879. DOI: 10.7150/ijbs.8879. View

Rastrick J, Stevenson C, Eltom S, Grace M, Davies M, Kilty I . Cigarette smoke induced airway inflammation is independent of NF-κB signalling. PLoS One. 2013; 8(1):e54128. PMC: 3551940. DOI: 10.1371/journal.pone.0054128. View

Rahman I, Morrison D, Donaldson K, MacNee W . Systemic oxidative stress in asthma, COPD, and smokers. Am J Respir Crit Care Med. 1996; 154(4 Pt 1):1055-60. DOI: 10.1164/ajrccm.154.4.8887607. View

. Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet Respir Med. 2017; 5(9):691-706. PMC: 5573769. DOI: 10.1016/S2213-2600(17)30293-X. View

Singh U, Devaraj S, Jialal I . Vitamin E, oxidative stress, and inflammation. Annu Rev Nutr. 2005; 25:151-74. DOI: 10.1146/annurev.nutr.24.012003.132446. View

Liu E, Kuang Y, He W, Xing X, Gu J . Casticin induces human glioma cell death through apoptosis and mitotic arrest. Cell Physiol Biochem. 2013; 31(6):805-14. DOI: 10.1159/000350098. View

10.

Lee H, Jung K, Lee H, Park S, Choi W, Bae H . Casticin, an active compound isolated from Vitex Fructus, ameliorates the cigarette smoke-induced acute lung inflammatory response in a murine model. Int Immunopharmacol. 2015; 28(2):1097-101. DOI: 10.1016/j.intimp.2015.07.041. View

11.

Rabe K, Watz H . Chronic obstructive pulmonary disease. Lancet. 2017; 389(10082):1931-1940. DOI: 10.1016/S0140-6736(17)31222-9. View

12.

Barnes P . New therapies for chronic obstructive pulmonary disease. Med Princ Pract. 2010; 19(5):330-8. DOI: 10.1159/000316368. View

13.

Sahiner U, Birben E, Erzurum S, Sackesen C, Kalayci O . Oxidative stress in asthma. World Allergy Organ J. 2012; 4(10):151-8. PMC: 3488912. DOI: 10.1097/WOX.0b013e318232389e. View

14.

Barnes P, Celli B . Systemic manifestations and comorbidities of COPD. Eur Respir J. 2009; 33(5):1165-85. DOI: 10.1183/09031936.00128008. View

15.

Mortaz E, Adcock I, Ricciardolo F, Varahram M, Jamaati H, Velayati A . Anti-Inflammatory Effects of Lactobacillus Rahmnosus and Bifidobacterium Breve on Cigarette Smoke Activated Human Macrophages. PLoS One. 2015; 10(8):e0136455. PMC: 4552661. DOI: 10.1371/journal.pone.0136455. View

16.

Ma J, Yin G, Lu Z, Xie P, Zhou H, Liu J . Casticin prevents DSS induced ulcerative colitis in mice through inhibitions of NF-κB pathway and ROS signaling. Phytother Res. 2018; 32(9):1770-1783. DOI: 10.1002/ptr.6108. View

17.

Barnes P, Burney P, Silverman E, Celli B, Vestbo J, Wedzicha J . Chronic obstructive pulmonary disease. Nat Rev Dis Primers. 2016; 1:15076. DOI: 10.1038/nrdp.2015.76. View

18.

Lee S, Ahn K, Sung M, Park J, Ryu H, Lee H . Indacaterol inhibits tumor cell invasiveness and MMP-9 expression by suppressing IKK/NF-κB activation. Mol Cells. 2014; 37(8):585-91. PMC: 4145369. DOI: 10.14348/molcells.2014.0076. View

19.

Saradna A, Do D, Kumar S, Fu Q, Gao P . Macrophage polarization and allergic asthma. Transl Res. 2017; 191:1-14. PMC: 5776696. DOI: 10.1016/j.trsl.2017.09.002. View

20.

Boorsma C, Draijer C, Melgert B . Macrophage heterogeneity in respiratory diseases. Mediators Inflamm. 2013; 2013:769214. PMC: 3600198. DOI: 10.1155/2013/769214. View