Toxoplasma Effectors That Affect Pregnancy Outcome

Overview

Journal Trends Parasitol

Specialty Parasitology

Date 2020 Nov 25

PMID 33234405

Citations 16

Authors

David Arranz-Solis

Debanjan Mukhopadhyay

Jeroen J P Saeij

Affiliations

Soon will be listed here.

Abstract

As an immune-privileged organ, the placenta can tolerate the introduction of antigens without inducing a strong inflammatory response that would lead to abortion. However, for the control of intracellular pathogens, a strong Th1 response characterized by the production of interferon-γ is needed. Thus, invasion of the placenta by intracellular parasites puts the maternal immune system in a quandary: The proinflammatory response needed to eliminate the pathogen can also lead to abortion. Toxoplasma is a highly successful parasite that causes lifelong chronic infections and is a major cause of abortions in humans and livestock. Here, we discuss how Toxoplasma strain type and parasite effectors influence host cell signaling pathways, and we speculate about how this might affect the outcome of gestation.

Citing Articles

Trem2/Syk/PI3K axis contributes to the host protection against Toxoplasma gondii-induced adverse pregnancy outcomes via modulating decidual macrophages.

Wang Q, Cao Y, Ye S, Ding M, Ge W, Liang Y PLoS Pathog. 2024; 20(9):e1012543.

PMID: 39250507 PMC: 11412541. DOI: 10.1371/journal.ppat.1012543.

CCR2-dependent placental migration of inflammatory monocytes suppresses abnormal pregnancies caused by Toxoplasma gondii infection.

Kamiyama N, Ueno M, Sasaki Y, Chalalai T, Sachi N, Ozaka S Int Immunol. 2024; 37(1):39-52.

PMID: 39051675 PMC: 11587896. DOI: 10.1093/intimm/dxae046.

Identification of novel biomarkers for anti- IgM detection and the potential application in rapid diagnostic fluorescent tests.

Nguyen M, Yeo S, Park H Front Microbiol. 2024; 15:1385582.

PMID: 38894968 PMC: 11184589. DOI: 10.3389/fmicb.2024.1385582.

Decidual natural killer cells dysfunction is caused by IDO downregulation in dMDSCs with Toxoplasma gondii infection.

Wang Y, Zhao X, Li Z, Wang W, Jiang Y, Zhang H Commun Biol. 2024; 7(1):669.

PMID: 38822095 PMC: 11143278. DOI: 10.1038/s42003-024-06365-5.

Single-cell transcriptomic analysis of decidual immune cell landscape in the occurrence of adverse pregnancy outcomes induced by Toxoplasma gondii infection.

Fu T, Wang X, Zhao X, Jiang Y, Liu X, Zhang H Parasit Vectors. 2024; 17(1):213.

PMID: 38730500 PMC: 11088043. DOI: 10.1186/s13071-024-06266-w.

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