Predictors and Biomarkers of Subclinical Leaflet Thrombosis After Transcatheter Aortic Valve Implantation

Overview

Journal J Clin Med

Specialty General Medicine

Date 2020 Nov 25

PMID 33233321

Citations 5

Authors

Katarzyna Pieniak

Szymon Jedrzejczyk

Olaf Domaszk

Kajetan Grodecki

Bartosz Rymuza

Zenon Huczek

Janusz Kochman

Krzysztof J Filipiak

Aleksandra Gasecka

Affiliations

Soon will be listed here.

Abstract

Transcatheter aortic valve implantation (TAVI) is a recent revolutionary treatment for high-risk patients with severe aortic stenosis who are not suitable for surgery, expanding to intermediate and low-risk patients. Valve leaflet thrombosis (LT) is a potentially fatal complication after TAVI. The incidence of subclinical LT is as high as 25% among patients in the first year after TAVI. Subclinical LT may evolve into symptomatic thrombosis or lead to premature bioprosthesis degeneration, increasing the risk of neurological complications. Because imaging-based methods have limited sensitivity to detect subclinical LT, there is an urgent need for predictors and biomarkers that would make it possible to predict LT after TAVI. Here, we summarize recent data regarding (i) patient-related, (ii) procedure-related, (iii) blood-based and (iv) imaging predictors and biomarkers which might be useful for the early diagnosis of subclinical LT after TAVI. Prevention of LT might offer an opportunity to improve risk stratification and tailor therapy after TAVI.

Citing Articles

Prothrombotic States in Transcatheter Heart Valve Leaflet Thrombosis (PROSTHESIS): Rationale and Early Results of the Observational Cohort Study.

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Thrombosis of Bioprosthetic Aortic Valve: Is the Entire Arsenal Deployed?.

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Prediction model for leaflet thrombosis in patients undergoing transcatheter aortic valve implantation: the EFFORT study.

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Circulating Monocyte Subsets and Transcatheter Aortic Valve Replacement.

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