Rise of TRIM8: A Molecule of Duality

Overview

Journal Mol Ther Nucleic Acids

Publisher Cell Press

Date 2020 Nov 24

PMID 33230447

Citations 18

Authors

Utsa Bhaduri

Giuseppe Merla

Affiliations

Soon will be listed here.

Abstract

The human tripartite motif containing protein 8 (TRIM8), a member of TRIM family proteins, is known to play a dual role as both tumor suppressor and oncogene, and to function at the crosstalk of cancer and innate immunity. In this review, in addition to accumulating recent corroborations that endorse this dual character of TRIM8, we appraise the game-changing capacity of TRIM8 under stress conditions against the backdrop of cell proliferation, apoptosis, and cancer, and also highlight the duality of TRIM8 in multiple contexts like cellular localization, stress-induced conditions, and E3 ubiquitin ligase activity. Finally, we discuss the emerging role of TRIM8 during bipolar spindle formation and mitotic progression, and its growing sphere of influence across multiple human cancers and pathologies, and suggest TRIM8-linked axes that can be modulated further for anti-cancer therapeutics development.

Citing Articles

Focal segmental glomerulosclerosis and neurogenic bladder in a Chinese patient with a novel pathogenic variation in TRIM8 gene: A case report.

Luo D, Long Y, Liu L, Chen X, Guo Y SAGE Open Med Case Rep. 2024; 12:2050313X241305905.

PMID: 39669799 PMC: 11635891. DOI: 10.1177/2050313X241305905.

Variants loci and phenotype correlation of related neuro-renal syndrome: three cases reports and literature review.

Lv Q, Niu Y, Xu Z, Qin J, Yang Z Front Neurol. 2024; 15:1410187.

PMID: 39416667 PMC: 11482035. DOI: 10.3389/fneur.2024.1410187.

TRIM8 as a predictor for prognosis in childhood acute lymphoblastic leukemia based on a signature of neutrophil extracellular traps.

Tin W, Xiao C, Sun K, Zhao Y, Xie M, Zheng J Front Oncol. 2024; 14:1427776.

PMID: 39224802 PMC: 11366590. DOI: 10.3389/fonc.2024.1427776.

TRIM8 Promotes Proliferation, Invasion, and Migration of Cervical Cancer Cells by Ubiquitinating and Degrading SOCS1.

Yu C, Wang J, Li Y Biochem Genet. 2024; .

PMID: 38918306 DOI: 10.1007/s10528-024-10865-8.

Tripartite motif 8 promotes the progression of hepatocellular carcinoma via mediating ubiquitination of HNF1α.

Peng Y, Qian H, Xu W, Xiao M, Ding C, Liu F Cell Death Dis. 2024; 15(6):416.

PMID: 38879600 PMC: 11180176. DOI: 10.1038/s41419-024-06819-y.

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